Evidence for the unique function of docosahexaenoic acid during the evolution of the modern hominid brain View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1999-01

AUTHORS

M. A. Crawford, M. Bloom, C. L. Broadhurst, W. F. Schmidt, S. C. Cunnane, C. Galli, K. Gehbremeskel, F. Linseisen, J. Lloyd-Smith, J. Parkington

ABSTRACT

The African savanna ecosystem of the large mammals and primates was associated with a dramatic decline in relative brain capacity associated with little docosahexaenoic acid (DHA), which is required for brain structures and growth. The biochemistry implies that the expansion of the human brain required a plentiful source of preformed DHA. The richest source of DHA is the marine food chain, while the savanna environment offers very little of it. Consequently Homo sapiens could not have evolved on the savannas. Recent fossil evidence indicates that the lacustrine and marine food chain was being extensively exploited at the time cerebral expansion took place and suggests the alternative that the transition from the archaic to modern humans took place at the land/water interface. Contemporary data on tropical lakeshore dwellers reaffirm the above view with nutritional support for the vascular system, the development of which would have been a prerequisite for cerebral expansion. Both arachidonic acid and DHA would have been freely available from such habitats providing the double stimulus of preformed acyl components for the developing blood vessels and brain. The n-3 docosapentaenoic acid precursor (n-3 DPA) was the major n-3-metabolite in the savanna mammals. Despite this abundance, neither it nor the corresponding n-6 DPA was used for the photoreceptor nor the synapse. A substantial difference between DHA and other fatty acids is required to explain this high specificity. Studies on fluidity and other mechanical features of cell membranes did not reveal a difference of such magnitude between even alpha-linolenic acid and DHA sufficient to explain the exclusive use of DHA. We suggest that the evolution of the large human brain depended on a rich source of DHA from the land/water interface. We review a number of proposals for the possible influence of DHA on physical properties of the brain that are essential for its function. More... »

PAGES

s39-s47

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf02562227

DOI

http://dx.doi.org/10.1007/bf02562227

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1031776165

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/10419087


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0602", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Ecology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biological Evolution", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Brain", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Dietary Fats, Unsaturated", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Docosahexaenoic Acids", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fish Oils", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fishes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fossils", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hominidae", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "name": [
            "Institute of Brain Chemistry, N7 8DB, London, United Kingdom"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Crawford", 
        "givenName": "M. A.", 
        "id": "sg:person.0613261074.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0613261074.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of British Columbia", 
          "id": "https://www.grid.ac/institutes/grid.17091.3e", 
          "name": [
            "Department of Physics, University of British Columbia, V6T 1Z1, Vancouver, British Columbia, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bloom", 
        "givenName": "M.", 
        "id": "sg:person.01251027642.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01251027642.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "USDA Beltsville, Environmental Chemistry Laboratory, 20705, Maryland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Broadhurst", 
        "givenName": "C. L.", 
        "id": "sg:person.01122752712.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01122752712.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "USDA Beltsville, Environmental Chemistry Laboratory, 20705, Maryland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schmidt", 
        "givenName": "W. F.", 
        "id": "sg:person.0635222434.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0635222434.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Toronto", 
          "id": "https://www.grid.ac/institutes/grid.17063.33", 
          "name": [
            "Department of Nutritional Sciences, University of Toronto, M5S 3E2, Ontario, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cunnane", 
        "givenName": "S. C.", 
        "id": "sg:person.0575421337.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0575421337.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Milan", 
          "id": "https://www.grid.ac/institutes/grid.4708.b", 
          "name": [
            "Institute of Pharmacological Sciences, 20133, Milan, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Galli", 
        "givenName": "C.", 
        "id": "sg:person.011531450452.97", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011531450452.97"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Institute of Brain Chemistry, N7 8DB, London, United Kingdom"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gehbremeskel", 
        "givenName": "K.", 
        "id": "sg:person.01060500612.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01060500612.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of British Columbia", 
          "id": "https://www.grid.ac/institutes/grid.17091.3e", 
          "name": [
            "Department of Physics, University of British Columbia, V6T 1Z1, Vancouver, British Columbia, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Linseisen", 
        "givenName": "F.", 
        "id": "sg:person.012344324721.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012344324721.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of British Columbia", 
          "id": "https://www.grid.ac/institutes/grid.17091.3e", 
          "name": [
            "Department of Physics, University of British Columbia, V6T 1Z1, Vancouver, British Columbia, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lloyd-Smith", 
        "givenName": "J.", 
        "id": "sg:person.016560021124.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016560021124.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Archaeology Department, University of Capetown, Capetown, South Africa"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Parkington", 
        "givenName": "J.", 
        "id": "sg:person.01145405013.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145405013.37"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/s0140-6736(76)91476-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001014483"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1469-7998.1987.tb03733.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001170252"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1469-7998.1987.tb03733.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001170252"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1079/bjn19900063", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002078027"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1079/bjn19900063", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002078027"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0899-9007(96)00410-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003666260"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(97)11374-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004713281"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.272.16.10491", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006283151"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/jhev.1994.1034", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006663758"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/adc.72.3.198", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010082741"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0009-3084(94)90180-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010697869"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0009-3084(94)90180-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010697869"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1098/rstb.1992.0099", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013729649"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/jhev.1996.0048", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014579341"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/258171a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020243620", 
          "https://doi.org/10.1038/258171a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0047-2484(91)90054-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022053466"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/jhev.1996.0058", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025901828"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(96)01391-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027086461"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj1150025", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027123920"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj1150025", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027123920"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.bb.22.060193.001045", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028486873"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/pgmj.54.629.149", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030710058"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/pgmj.54.629.149", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030710058"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1079/pns19750051", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031815458"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1079/pns19750051", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031815458"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/32401", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037092499", 
          "https://doi.org/10.1038/32401"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/32401", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037092499", 
          "https://doi.org/10.1038/32401"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02522692", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041738154", 
          "https://doi.org/10.1007/bf02522692"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0009-3084(90)90063-w", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041744924"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0009-3084(90)90063-w", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041744924"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1079/bjn19980004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043528965"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1079/bjn19980004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043528965"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/jhev.1994.1017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044941881"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/jhev.1996.0014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045956628"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0006-3495(95)80422-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047511924"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.279.1.23", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048326733"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/9780470719862.ch16", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048962947"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1840702", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062509890"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.271.5254.1380", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062552405"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.280.5370.1730", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062561407"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1530/ror.0.0020105", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1067730853"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2307/2408653", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069917647"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079212011", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081467391", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000424010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082537717"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpregu.1995.268.2.r498", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082541306"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jn/127.1.146", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083048953"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083142097", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/ajcn/66.4.1032s", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083156498"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1999-01", 
    "datePublishedReg": "1999-01-01", 
    "description": "The African savanna ecosystem of the large mammals and primates was associated with a dramatic decline in relative brain capacity associated with little docosahexaenoic acid (DHA), which is required for brain structures and growth. The biochemistry implies that the expansion of the human brain required a plentiful source of preformed DHA. The richest source of DHA is the marine food chain, while the savanna environment offers very little of it. Consequently Homo sapiens could not have evolved on the savannas. Recent fossil evidence indicates that the lacustrine and marine food chain was being extensively exploited at the time cerebral expansion took place and suggests the alternative that the transition from the archaic to modern humans took place at the land/water interface. Contemporary data on tropical lakeshore dwellers reaffirm the above view with nutritional support for the vascular system, the development of which would have been a prerequisite for cerebral expansion. Both arachidonic acid and DHA would have been freely available from such habitats providing the double stimulus of preformed acyl components for the developing blood vessels and brain. The n-3 docosapentaenoic acid precursor (n-3 DPA) was the major n-3-metabolite in the savanna mammals. Despite this abundance, neither it nor the corresponding n-6 DPA was used for the photoreceptor nor the synapse. A substantial difference between DHA and other fatty acids is required to explain this high specificity. Studies on fluidity and other mechanical features of cell membranes did not reveal a difference of such magnitude between even alpha-linolenic acid and DHA sufficient to explain the exclusive use of DHA. We suggest that the evolution of the large human brain depended on a rich source of DHA from the land/water interface. We review a number of proposals for the possible influence of DHA on physical properties of the brain that are essential for its function.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/bf02562227", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1006395", 
        "issn": [
          "0024-4201", 
          "1558-9307"
        ], 
        "name": "Lipids", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "Suppl 1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "34"
      }
    ], 
    "name": "Evidence for the unique function of docosahexaenoic acid during the evolution of the modern hominid brain", 
    "pagination": "s39-s47", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "976005dda501324f2e7467047b474dbecf0ec73c4a07de6aa21f755e1eebb8a6"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "10419087"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0060450"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/bf02562227"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1031776165"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/bf02562227", 
      "https://app.dimensions.ai/details/publication/pub.1031776165"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T13:05", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8659_00000481.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007/BF02562227"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/bf02562227'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/bf02562227'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/bf02562227'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/bf02562227'


 

This table displays all metadata directly associated to this object as RDF triples.

308 TRIPLES      21 PREDICATES      79 URIs      31 LITERALS      19 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/bf02562227 schema:about N0cf9c33aaedd4230bf6fb0789a94a581
2 N46816efe05464c73874eff99c4bb3c64
3 N5551ad750b0f4bb0bba1da15e54a713a
4 N82611a60b42b4d618b32863eb166b892
5 N94ff434a3f504ef49b7e5da07a7739e2
6 N998747d426954be59a587c3d5646d0dd
7 Nb8b610ab78c94f2d98a1472a31d2332f
8 Nc89ba19856ad4cfaab211fa565fbe175
9 Nde642ea2a687470cab102d128d5cda27
10 Ne717c3264f754100a835198f3d857f9e
11 anzsrc-for:06
12 anzsrc-for:0602
13 schema:author Nc5a4a5fa8e8f45f69c72bbb2e4d34e4d
14 schema:citation sg:pub.10.1007/bf02522692
15 sg:pub.10.1038/258171a0
16 sg:pub.10.1038/32401
17 https://app.dimensions.ai/details/publication/pub.1079212011
18 https://app.dimensions.ai/details/publication/pub.1081467391
19 https://app.dimensions.ai/details/publication/pub.1083142097
20 https://doi.org/10.1001/jama.279.1.23
21 https://doi.org/10.1002/9780470719862.ch16
22 https://doi.org/10.1006/jhev.1994.1017
23 https://doi.org/10.1006/jhev.1994.1034
24 https://doi.org/10.1006/jhev.1996.0014
25 https://doi.org/10.1006/jhev.1996.0048
26 https://doi.org/10.1006/jhev.1996.0058
27 https://doi.org/10.1016/0009-3084(90)90063-w
28 https://doi.org/10.1016/0009-3084(94)90180-5
29 https://doi.org/10.1016/0047-2484(91)90054-y
30 https://doi.org/10.1016/s0006-3495(95)80422-4
31 https://doi.org/10.1016/s0140-6736(76)91476-8
32 https://doi.org/10.1016/s0140-6736(96)01391-8
33 https://doi.org/10.1016/s0140-6736(97)11374-5
34 https://doi.org/10.1016/s0899-9007(96)00410-8
35 https://doi.org/10.1042/bj1150025
36 https://doi.org/10.1074/jbc.272.16.10491
37 https://doi.org/10.1079/bjn19900063
38 https://doi.org/10.1079/bjn19980004
39 https://doi.org/10.1079/pns19750051
40 https://doi.org/10.1093/ajcn/66.4.1032s
41 https://doi.org/10.1093/jn/127.1.146
42 https://doi.org/10.1098/rstb.1992.0099
43 https://doi.org/10.1111/j.1469-7998.1987.tb03733.x
44 https://doi.org/10.1126/science.1840702
45 https://doi.org/10.1126/science.271.5254.1380
46 https://doi.org/10.1126/science.280.5370.1730
47 https://doi.org/10.1136/adc.72.3.198
48 https://doi.org/10.1136/pgmj.54.629.149
49 https://doi.org/10.1146/annurev.bb.22.060193.001045
50 https://doi.org/10.1152/ajpregu.1995.268.2.r498
51 https://doi.org/10.1159/000424010
52 https://doi.org/10.1530/ror.0.0020105
53 https://doi.org/10.2307/2408653
54 schema:datePublished 1999-01
55 schema:datePublishedReg 1999-01-01
56 schema:description The African savanna ecosystem of the large mammals and primates was associated with a dramatic decline in relative brain capacity associated with little docosahexaenoic acid (DHA), which is required for brain structures and growth. The biochemistry implies that the expansion of the human brain required a plentiful source of preformed DHA. The richest source of DHA is the marine food chain, while the savanna environment offers very little of it. Consequently Homo sapiens could not have evolved on the savannas. Recent fossil evidence indicates that the lacustrine and marine food chain was being extensively exploited at the time cerebral expansion took place and suggests the alternative that the transition from the archaic to modern humans took place at the land/water interface. Contemporary data on tropical lakeshore dwellers reaffirm the above view with nutritional support for the vascular system, the development of which would have been a prerequisite for cerebral expansion. Both arachidonic acid and DHA would have been freely available from such habitats providing the double stimulus of preformed acyl components for the developing blood vessels and brain. The n-3 docosapentaenoic acid precursor (n-3 DPA) was the major n-3-metabolite in the savanna mammals. Despite this abundance, neither it nor the corresponding n-6 DPA was used for the photoreceptor nor the synapse. A substantial difference between DHA and other fatty acids is required to explain this high specificity. Studies on fluidity and other mechanical features of cell membranes did not reveal a difference of such magnitude between even alpha-linolenic acid and DHA sufficient to explain the exclusive use of DHA. We suggest that the evolution of the large human brain depended on a rich source of DHA from the land/water interface. We review a number of proposals for the possible influence of DHA on physical properties of the brain that are essential for its function.
57 schema:genre research_article
58 schema:inLanguage en
59 schema:isAccessibleForFree false
60 schema:isPartOf N50569de250524725b579a4f016744b08
61 Na25208d895b14ed8b00ef31f65639c81
62 sg:journal.1006395
63 schema:name Evidence for the unique function of docosahexaenoic acid during the evolution of the modern hominid brain
64 schema:pagination s39-s47
65 schema:productId N4d55a36ebc6b44788d1ff192902c08dc
66 N6af0b1e6817b45308eb5a4f08937fc9e
67 Na87045779633490fa7f9a2c434a59c51
68 Nb7727bef940049fe89b83da360f7cb4f
69 Ne062452d8fd649ac9443c01bfe235add
70 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031776165
71 https://doi.org/10.1007/bf02562227
72 schema:sdDatePublished 2019-04-10T13:05
73 schema:sdLicense https://scigraph.springernature.com/explorer/license/
74 schema:sdPublisher Nd790cefe92ba450683179f9bd886bb6f
75 schema:url http://link.springer.com/10.1007/BF02562227
76 sgo:license sg:explorer/license/
77 sgo:sdDataset articles
78 rdf:type schema:ScholarlyArticle
79 N04593ec3593b4a7b9428c4fde4715465 rdf:first sg:person.016560021124.01
80 rdf:rest N3b0ba95f9c114bafa36fbb07299f3617
81 N0cf9c33aaedd4230bf6fb0789a94a581 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
82 schema:name Fish Oils
83 rdf:type schema:DefinedTerm
84 N1cb309edc4844f10b45fe6a059c57e7b rdf:first sg:person.01122752712.28
85 rdf:rest N54d340ffb04f43cea1ec3be7bc94c2b1
86 N3b0ba95f9c114bafa36fbb07299f3617 rdf:first sg:person.01145405013.37
87 rdf:rest rdf:nil
88 N41e18290b14b4de3b7498850e0774ac6 rdf:first sg:person.012344324721.31
89 rdf:rest N04593ec3593b4a7b9428c4fde4715465
90 N46816efe05464c73874eff99c4bb3c64 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name Dietary Fats, Unsaturated
92 rdf:type schema:DefinedTerm
93 N4d55a36ebc6b44788d1ff192902c08dc schema:name nlm_unique_id
94 schema:value 0060450
95 rdf:type schema:PropertyValue
96 N50569de250524725b579a4f016744b08 schema:issueNumber Suppl 1
97 rdf:type schema:PublicationIssue
98 N54d340ffb04f43cea1ec3be7bc94c2b1 rdf:first sg:person.0635222434.46
99 rdf:rest Na6c366831a654f5c827bb626fa0d9cb9
100 N5505129eb3c5441198363bdb09ac9b69 schema:name Institute of Brain Chemistry, N7 8DB, London, United Kingdom
101 rdf:type schema:Organization
102 N5551ad750b0f4bb0bba1da15e54a713a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Biological Evolution
104 rdf:type schema:DefinedTerm
105 N5a70192db66249749d17194dc6d05300 rdf:first sg:person.01251027642.54
106 rdf:rest N1cb309edc4844f10b45fe6a059c57e7b
107 N5f342102c46e4dc185621e64412626eb schema:name Archaeology Department, University of Capetown, Capetown, South Africa
108 rdf:type schema:Organization
109 N615865136ea74b959853061b9ce41a66 schema:name USDA Beltsville, Environmental Chemistry Laboratory, 20705, Maryland
110 rdf:type schema:Organization
111 N6af0b1e6817b45308eb5a4f08937fc9e schema:name dimensions_id
112 schema:value pub.1031776165
113 rdf:type schema:PropertyValue
114 N82611a60b42b4d618b32863eb166b892 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Docosahexaenoic Acids
116 rdf:type schema:DefinedTerm
117 N89b5823b134c4d97a5cad47bfc586d27 schema:name USDA Beltsville, Environmental Chemistry Laboratory, 20705, Maryland
118 rdf:type schema:Organization
119 N94ff434a3f504ef49b7e5da07a7739e2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Humans
121 rdf:type schema:DefinedTerm
122 N998747d426954be59a587c3d5646d0dd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Hominidae
124 rdf:type schema:DefinedTerm
125 Na25208d895b14ed8b00ef31f65639c81 schema:volumeNumber 34
126 rdf:type schema:PublicationVolume
127 Na6c366831a654f5c827bb626fa0d9cb9 rdf:first sg:person.0575421337.41
128 rdf:rest Ne9435e9e849d4be1a25bbc282538a3db
129 Na7ad61afb501465891c6d4a2f38d3796 schema:name Institute of Brain Chemistry, N7 8DB, London, United Kingdom
130 rdf:type schema:Organization
131 Na87045779633490fa7f9a2c434a59c51 schema:name doi
132 schema:value 10.1007/bf02562227
133 rdf:type schema:PropertyValue
134 Nb7727bef940049fe89b83da360f7cb4f schema:name readcube_id
135 schema:value 976005dda501324f2e7467047b474dbecf0ec73c4a07de6aa21f755e1eebb8a6
136 rdf:type schema:PropertyValue
137 Nb8b610ab78c94f2d98a1472a31d2332f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Fossils
139 rdf:type schema:DefinedTerm
140 Nc5a4a5fa8e8f45f69c72bbb2e4d34e4d rdf:first sg:person.0613261074.52
141 rdf:rest N5a70192db66249749d17194dc6d05300
142 Nc89ba19856ad4cfaab211fa565fbe175 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Brain
144 rdf:type schema:DefinedTerm
145 Nd790cefe92ba450683179f9bd886bb6f schema:name Springer Nature - SN SciGraph project
146 rdf:type schema:Organization
147 Nd9b60311c04b4172a912a83bc5904bee rdf:first sg:person.01060500612.18
148 rdf:rest N41e18290b14b4de3b7498850e0774ac6
149 Nde642ea2a687470cab102d128d5cda27 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Animals
151 rdf:type schema:DefinedTerm
152 Ne062452d8fd649ac9443c01bfe235add schema:name pubmed_id
153 schema:value 10419087
154 rdf:type schema:PropertyValue
155 Ne717c3264f754100a835198f3d857f9e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Fishes
157 rdf:type schema:DefinedTerm
158 Ne9435e9e849d4be1a25bbc282538a3db rdf:first sg:person.011531450452.97
159 rdf:rest Nd9b60311c04b4172a912a83bc5904bee
160 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
161 schema:name Biological Sciences
162 rdf:type schema:DefinedTerm
163 anzsrc-for:0602 schema:inDefinedTermSet anzsrc-for:
164 schema:name Ecology
165 rdf:type schema:DefinedTerm
166 sg:journal.1006395 schema:issn 0024-4201
167 1558-9307
168 schema:name Lipids
169 rdf:type schema:Periodical
170 sg:person.01060500612.18 schema:affiliation N5505129eb3c5441198363bdb09ac9b69
171 schema:familyName Gehbremeskel
172 schema:givenName K.
173 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01060500612.18
174 rdf:type schema:Person
175 sg:person.01122752712.28 schema:affiliation N615865136ea74b959853061b9ce41a66
176 schema:familyName Broadhurst
177 schema:givenName C. L.
178 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01122752712.28
179 rdf:type schema:Person
180 sg:person.01145405013.37 schema:affiliation N5f342102c46e4dc185621e64412626eb
181 schema:familyName Parkington
182 schema:givenName J.
183 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145405013.37
184 rdf:type schema:Person
185 sg:person.011531450452.97 schema:affiliation https://www.grid.ac/institutes/grid.4708.b
186 schema:familyName Galli
187 schema:givenName C.
188 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011531450452.97
189 rdf:type schema:Person
190 sg:person.012344324721.31 schema:affiliation https://www.grid.ac/institutes/grid.17091.3e
191 schema:familyName Linseisen
192 schema:givenName F.
193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012344324721.31
194 rdf:type schema:Person
195 sg:person.01251027642.54 schema:affiliation https://www.grid.ac/institutes/grid.17091.3e
196 schema:familyName Bloom
197 schema:givenName M.
198 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01251027642.54
199 rdf:type schema:Person
200 sg:person.016560021124.01 schema:affiliation https://www.grid.ac/institutes/grid.17091.3e
201 schema:familyName Lloyd-Smith
202 schema:givenName J.
203 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016560021124.01
204 rdf:type schema:Person
205 sg:person.0575421337.41 schema:affiliation https://www.grid.ac/institutes/grid.17063.33
206 schema:familyName Cunnane
207 schema:givenName S. C.
208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0575421337.41
209 rdf:type schema:Person
210 sg:person.0613261074.52 schema:affiliation Na7ad61afb501465891c6d4a2f38d3796
211 schema:familyName Crawford
212 schema:givenName M. A.
213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0613261074.52
214 rdf:type schema:Person
215 sg:person.0635222434.46 schema:affiliation N89b5823b134c4d97a5cad47bfc586d27
216 schema:familyName Schmidt
217 schema:givenName W. F.
218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0635222434.46
219 rdf:type schema:Person
220 sg:pub.10.1007/bf02522692 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041738154
221 https://doi.org/10.1007/bf02522692
222 rdf:type schema:CreativeWork
223 sg:pub.10.1038/258171a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020243620
224 https://doi.org/10.1038/258171a0
225 rdf:type schema:CreativeWork
226 sg:pub.10.1038/32401 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037092499
227 https://doi.org/10.1038/32401
228 rdf:type schema:CreativeWork
229 https://app.dimensions.ai/details/publication/pub.1079212011 schema:CreativeWork
230 https://app.dimensions.ai/details/publication/pub.1081467391 schema:CreativeWork
231 https://app.dimensions.ai/details/publication/pub.1083142097 schema:CreativeWork
232 https://doi.org/10.1001/jama.279.1.23 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048326733
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1002/9780470719862.ch16 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048962947
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1006/jhev.1994.1017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044941881
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1006/jhev.1994.1034 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006663758
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1006/jhev.1996.0014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045956628
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1006/jhev.1996.0048 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014579341
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1006/jhev.1996.0058 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025901828
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1016/0009-3084(90)90063-w schema:sameAs https://app.dimensions.ai/details/publication/pub.1041744924
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1016/0009-3084(94)90180-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010697869
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1016/0047-2484(91)90054-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1022053466
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1016/s0006-3495(95)80422-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047511924
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1016/s0140-6736(76)91476-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001014483
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1016/s0140-6736(96)01391-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027086461
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1016/s0140-6736(97)11374-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004713281
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1016/s0899-9007(96)00410-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003666260
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1042/bj1150025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027123920
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1074/jbc.272.16.10491 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006283151
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1079/bjn19900063 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002078027
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1079/bjn19980004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043528965
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1079/pns19750051 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031815458
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1093/ajcn/66.4.1032s schema:sameAs https://app.dimensions.ai/details/publication/pub.1083156498
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1093/jn/127.1.146 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083048953
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1098/rstb.1992.0099 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013729649
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1111/j.1469-7998.1987.tb03733.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1001170252
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1126/science.1840702 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062509890
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1126/science.271.5254.1380 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062552405
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1126/science.280.5370.1730 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062561407
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1136/adc.72.3.198 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010082741
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1136/pgmj.54.629.149 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030710058
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1146/annurev.bb.22.060193.001045 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028486873
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1152/ajpregu.1995.268.2.r498 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082541306
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1159/000424010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082537717
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1530/ror.0.0020105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1067730853
297 rdf:type schema:CreativeWork
298 https://doi.org/10.2307/2408653 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069917647
299 rdf:type schema:CreativeWork
300 https://www.grid.ac/institutes/grid.17063.33 schema:alternateName University of Toronto
301 schema:name Department of Nutritional Sciences, University of Toronto, M5S 3E2, Ontario, Canada
302 rdf:type schema:Organization
303 https://www.grid.ac/institutes/grid.17091.3e schema:alternateName University of British Columbia
304 schema:name Department of Physics, University of British Columbia, V6T 1Z1, Vancouver, British Columbia, Canada
305 rdf:type schema:Organization
306 https://www.grid.ac/institutes/grid.4708.b schema:alternateName University of Milan
307 schema:name Institute of Pharmacological Sciences, 20133, Milan, Italy
308 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...