Drug resistance inPlasmodium falciparum malaria View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1999-03

AUTHORS

D. C. Warhurst

ABSTRACT

Four classes of drugs are reviewed: blood schizontocides acting only on the hemoglobin-digesting blood stages, the antifolates which attack tetrahydrofolate synthesis in all the growing stages, antimitochondrials affecting synthesis and electron transport, and 8-aminoquinolines which interfere with redox processes. Drug efflux via a multidrug resistance membrane protein, and the production of a protein competing with the drug for the target hemin are thought to be responsible for resistance to blood schizontocides. Structural changes in target enzymes are responsible for easily-developed resistance to antifolates and antimitochondrials. The judicious use of drug combinations can help to avoid development of resistance and combat resistant infections, but new drugs are urgently needed. More... »

PAGES

s55-s58

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf02561674

DOI

http://dx.doi.org/10.1007/bf02561674

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1019874759

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/10885831


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