Reinvestigation of the antioxidant properties of conjugated linoleic acid View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1995-07

AUTHORS

Jeroen J. M. van den Berg, Nancy E. Cook, Diane L. Tribble

ABSTRACT

Despite repeated suggestions that antioxidant activity of conjugated linoleic acid (CLA), a collective of conjugated dienoic isomers of linoleic acid, underlies its reported anticarcinogenic and antiatherosclerotic effects, the antioxidant properties of CLA remain ill-defined. Therefore, this study was undertaken to gain more insight into the mechanism of potential CLA antioxidant activity. It was tested whether CLA could protect membranes composed of 1-palmitoyl-2-linoleoyl phosphatidylcholine (PLPC) from oxidative modification under conditions of metal ion-dependent or -independent oxidative stress. Progress of oxidation was determined by direct spectrophotometric measurement of conjugated diene formation and by gas chromatographic/mass spectrometric analysis of fatty acids. The oxidative susceptibility of CLA was higher than that of linoleic acid, and comparable to arachidonic acid. When oxidation of PLPC (1.0 mM) was initiated using the lipid-soluble 2,2'-azobis(2,4-dimethylvaleronitrile) or the water-soluble 2,2'-azobis(2-amidinopropane) hydrochloride, the radical scavengers vitamin E and butylated hydroxytoluene (BHT) at 0.75 microM efficiently inhibited PLPC oxidation, as evident from a clear lag phase. In contrast, 0.75 microM CLA did not have any significant effect on PLPC oxidation. Inhibition of PLPC oxidation by higher concentrations of CLA appeared due to competition, not to an antioxidant effect. When oxidation of PLPC was initiated by hydrogen peroxide/Fe2+ (500 microM/0.05-20 microM), both vitamin E (1 microM) and ethylene glycol-bis(aminoethyl ether) tetraacetic acid (50 microM) efficiently inhibited PLPC oxidation. However, CLA (1-50 microM) did not show a clear protective effect under any of the conditions tested. We conclude that CLA, under these test conditions, does not act as an efficient radical scavenger in any way comparable to vitamin E or BHT. CLA also does not appear to be converted into a metal chelator under metal-ion dependent oxidative stress, as had previously been suggested. On the basis of our observations, a role for CLA as an antioxidant does not seem plausible. More... »

PAGES

599-605

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf02536996

DOI

http://dx.doi.org/10.1007/bf02536996

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1052229443

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/7564914


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