Pharmacokinetics of the thioether phospholipid analogue BM 41.440 in rats View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1987-11

AUTHORS

Dieter B. J. Herrmann, Eberhard Besenfelder, Uwe Bicker, Wulf Pahlke, Erwin Böhm

ABSTRACT

BM 41.440 (1-hexadecylmercapto-2-methoxymethyl-rac-glycero-3-phosphocholine) is a cytotoxic thioether phospholipid analogue that recently has entered phase I trials in cancer patients. The objective of this study was to evaluate the pharmacokinetics of this compound in female rats after administration of a single oral dose (15 mg/kg body weight [bw] ). Furthermore, BM 41.440 serum concentrations were determined under a daily oral treatment of up to 13 weeks. Blood samples were obtained via permanent catheters from the femoral arteries before and after drug administration for a total of 120 hr. Urine was collected in 24 hr-intervals for 120 hr; the volume was measured, and aliquots were stored at -20 C until analytical determination of the thioether derivative. BM 41.440 was assayed in serum and urine by means of a specific, newly developed reverse-phase high pressure liquid chromatography technique. Mean maximum serum concentrations (1.7 micrograms/ml, n = 4 animals) were attained after seven hr. A terminal half-life of ca. 27 hr was calculated from the rate constant for the terminal elimination phase (lambda z approximately 0.026/hr). The mean serum BM 41.440 concentration-time-area-under-the-curve was 52.9 mg X hr/l. The ratio of total body clearance to absorption fraction was 4.7 ml/min X kg bw. Only a small amount of the drug was found in the urine. The quantity excreted in the urine during a 24 hr-interval never exceeded 1.5% of the administered dose.(ABSTRACT TRUNCATED AT 250 WORDS) More... »

PAGES

952-954

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf02535562

DOI

http://dx.doi.org/10.1007/bf02535562

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1028686569

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/3444391


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Administration, Oral", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Organophosphates", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Organophosphorus Compounds", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phospholipid Ethers", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats, Inbred Strains", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Roche (Germany)", 
          "id": "https://www.grid.ac/institutes/grid.424277.0", 
          "name": [
            "Department of Immunopharmacology and Cancer Research, Boehringer Mannheim GmbH, Sandhofer Strasse 116, 6800, Mannheim 31, Federal Republic of Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Herrmann", 
        "givenName": "Dieter B. J.", 
        "id": "sg:person.01014522713.61", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01014522713.61"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Roche (Germany)", 
          "id": "https://www.grid.ac/institutes/grid.424277.0", 
          "name": [
            "Department of Immunopharmacology and Cancer Research, Boehringer Mannheim GmbH, Sandhofer Strasse 116, 6800, Mannheim 31, Federal Republic of Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Besenfelder", 
        "givenName": "Eberhard", 
        "id": "sg:person.01051322226.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01051322226.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Roche (Germany)", 
          "id": "https://www.grid.ac/institutes/grid.424277.0", 
          "name": [
            "Department of Immunopharmacology and Cancer Research, Boehringer Mannheim GmbH, Sandhofer Strasse 116, 6800, Mannheim 31, Federal Republic of Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bicker", 
        "givenName": "Uwe", 
        "id": "sg:person.01216213761.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01216213761.48"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Roche (Germany)", 
          "id": "https://www.grid.ac/institutes/grid.424277.0", 
          "name": [
            "Department of Immunopharmacology and Cancer Research, Boehringer Mannheim GmbH, Sandhofer Strasse 116, 6800, Mannheim 31, Federal Republic of Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pahlke", 
        "givenName": "Wulf", 
        "id": "sg:person.01000145513.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01000145513.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Roche (Germany)", 
          "id": "https://www.grid.ac/institutes/grid.424277.0", 
          "name": [
            "Department of Immunopharmacology and Cancer Research, Boehringer Mannheim GmbH, Sandhofer Strasse 116, 6800, Mannheim 31, Federal Republic of Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "B\u00f6hm", 
        "givenName": "Erwin", 
        "id": "sg:person.01251326701.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01251326701.00"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/b978-0-12-730950-7.50010-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004665348"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0005-2760(78)90125-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028202320"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0005-2760(78)90125-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028202320"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00402775", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032283330", 
          "https://doi.org/10.1007/bf00402775"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00402775", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032283330", 
          "https://doi.org/10.1007/bf00402775"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02535565", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042782497", 
          "https://doi.org/10.1007/bf02535565"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0014-2964(80)90179-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050501128"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/78.6.1087", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079770530"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079910651", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079998654", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/75.3.423", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079999128"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1080095269", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081236625", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082054654", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1987-11", 
    "datePublishedReg": "1987-11-01", 
    "description": "BM 41.440 (1-hexadecylmercapto-2-methoxymethyl-rac-glycero-3-phosphocholine) is a cytotoxic thioether phospholipid analogue that recently has entered phase I trials in cancer patients. The objective of this study was to evaluate the pharmacokinetics of this compound in female rats after administration of a single oral dose (15 mg/kg body weight [bw] ). Furthermore, BM 41.440 serum concentrations were determined under a daily oral treatment of up to 13 weeks. Blood samples were obtained via permanent catheters from the femoral arteries before and after drug administration for a total of 120 hr. Urine was collected in 24 hr-intervals for 120 hr; the volume was measured, and aliquots were stored at -20 C until analytical determination of the thioether derivative. BM 41.440 was assayed in serum and urine by means of a specific, newly developed reverse-phase high pressure liquid chromatography technique. Mean maximum serum concentrations (1.7 micrograms/ml, n = 4 animals) were attained after seven hr. A terminal half-life of ca. 27 hr was calculated from the rate constant for the terminal elimination phase (lambda z approximately 0.026/hr). The mean serum BM 41.440 concentration-time-area-under-the-curve was 52.9 mg X hr/l. The ratio of total body clearance to absorption fraction was 4.7 ml/min X kg bw. Only a small amount of the drug was found in the urine. The quantity excreted in the urine during a 24 hr-interval never exceeded 1.5% of the administered dose.(ABSTRACT TRUNCATED AT 250 WORDS)", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/bf02535562", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1006395", 
        "issn": [
          "0024-4201", 
          "1558-9307"
        ], 
        "name": "Lipids", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "11", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "22"
      }
    ], 
    "name": "Pharmacokinetics of the thioether phospholipid analogue BM 41.440 in rats", 
    "pagination": "952-954", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "88a7913b09740014284befea58daf2121ac8bad6634228555eea9d6189b5aecb"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "3444391"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0060450"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/bf02535562"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1028686569"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/bf02535562", 
      "https://app.dimensions.ai/details/publication/pub.1028686569"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T14:03", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8660_00000489.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007/BF02535562"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/bf02535562'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/bf02535562'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/bf02535562'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/bf02535562'


 

This table displays all metadata directly associated to this object as RDF triples.

158 TRIPLES      21 PREDICATES      48 URIs      28 LITERALS      16 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/bf02535562 schema:about N07b4382d626547f99198f6db3ed1066c
2 N29fe5b151e7343ecb688111519f2b7b4
3 N430b6c0968a449b59061afbe0f79fc44
4 N8248b2eb9c45417eb7a271036c7dff02
5 N9d6946a26b9a400bacf49fb744baaae9
6 Nb047b432f2b049c18d2618b4fff232f1
7 Nd07bc60868654f4099e745994fa92077
8 anzsrc-for:11
9 anzsrc-for:1103
10 schema:author N875c5f10713c474a8611b6fab27e4da9
11 schema:citation sg:pub.10.1007/bf00402775
12 sg:pub.10.1007/bf02535565
13 https://app.dimensions.ai/details/publication/pub.1079910651
14 https://app.dimensions.ai/details/publication/pub.1079998654
15 https://app.dimensions.ai/details/publication/pub.1080095269
16 https://app.dimensions.ai/details/publication/pub.1081236625
17 https://app.dimensions.ai/details/publication/pub.1082054654
18 https://doi.org/10.1016/0005-2760(78)90125-x
19 https://doi.org/10.1016/0014-2964(80)90179-6
20 https://doi.org/10.1016/b978-0-12-730950-7.50010-0
21 https://doi.org/10.1093/jnci/75.3.423
22 https://doi.org/10.1093/jnci/78.6.1087
23 schema:datePublished 1987-11
24 schema:datePublishedReg 1987-11-01
25 schema:description BM 41.440 (1-hexadecylmercapto-2-methoxymethyl-rac-glycero-3-phosphocholine) is a cytotoxic thioether phospholipid analogue that recently has entered phase I trials in cancer patients. The objective of this study was to evaluate the pharmacokinetics of this compound in female rats after administration of a single oral dose (15 mg/kg body weight [bw] ). Furthermore, BM 41.440 serum concentrations were determined under a daily oral treatment of up to 13 weeks. Blood samples were obtained via permanent catheters from the femoral arteries before and after drug administration for a total of 120 hr. Urine was collected in 24 hr-intervals for 120 hr; the volume was measured, and aliquots were stored at -20 C until analytical determination of the thioether derivative. BM 41.440 was assayed in serum and urine by means of a specific, newly developed reverse-phase high pressure liquid chromatography technique. Mean maximum serum concentrations (1.7 micrograms/ml, n = 4 animals) were attained after seven hr. A terminal half-life of ca. 27 hr was calculated from the rate constant for the terminal elimination phase (lambda z approximately 0.026/hr). The mean serum BM 41.440 concentration-time-area-under-the-curve was 52.9 mg X hr/l. The ratio of total body clearance to absorption fraction was 4.7 ml/min X kg bw. Only a small amount of the drug was found in the urine. The quantity excreted in the urine during a 24 hr-interval never exceeded 1.5% of the administered dose.(ABSTRACT TRUNCATED AT 250 WORDS)
26 schema:genre research_article
27 schema:inLanguage en
28 schema:isAccessibleForFree false
29 schema:isPartOf N3a3a240a2e854c41a1994aed84a9bef3
30 Nc2f1e192dd3541c5b88db2b70f5feed3
31 sg:journal.1006395
32 schema:name Pharmacokinetics of the thioether phospholipid analogue BM 41.440 in rats
33 schema:pagination 952-954
34 schema:productId N01cf4a466dd5455bb3202b7c360f6886
35 N06099d2a1a094735815939da6b8b2386
36 N2144b5bd96a940bbb012d1b61a588611
37 N500c9826e5b44693afe88420399f2ec1
38 N5a223ce2ea5044fe842de50d30b51d72
39 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028686569
40 https://doi.org/10.1007/bf02535562
41 schema:sdDatePublished 2019-04-10T14:03
42 schema:sdLicense https://scigraph.springernature.com/explorer/license/
43 schema:sdPublisher N797bdfbbcc1f4b50b419c5c670bc661a
44 schema:url http://link.springer.com/10.1007/BF02535562
45 sgo:license sg:explorer/license/
46 sgo:sdDataset articles
47 rdf:type schema:ScholarlyArticle
48 N01cf4a466dd5455bb3202b7c360f6886 schema:name dimensions_id
49 schema:value pub.1028686569
50 rdf:type schema:PropertyValue
51 N06099d2a1a094735815939da6b8b2386 schema:name pubmed_id
52 schema:value 3444391
53 rdf:type schema:PropertyValue
54 N07b4382d626547f99198f6db3ed1066c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
55 schema:name Administration, Oral
56 rdf:type schema:DefinedTerm
57 N2144b5bd96a940bbb012d1b61a588611 schema:name nlm_unique_id
58 schema:value 0060450
59 rdf:type schema:PropertyValue
60 N29fe5b151e7343ecb688111519f2b7b4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
61 schema:name Rats
62 rdf:type schema:DefinedTerm
63 N3440d7a1858c4cb9a9a41f2ba3309499 rdf:first sg:person.01216213761.48
64 rdf:rest N91c94f050b7241d69f576578449a0955
65 N3a3a240a2e854c41a1994aed84a9bef3 schema:volumeNumber 22
66 rdf:type schema:PublicationVolume
67 N430b6c0968a449b59061afbe0f79fc44 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
68 schema:name Organophosphates
69 rdf:type schema:DefinedTerm
70 N500c9826e5b44693afe88420399f2ec1 schema:name readcube_id
71 schema:value 88a7913b09740014284befea58daf2121ac8bad6634228555eea9d6189b5aecb
72 rdf:type schema:PropertyValue
73 N5a223ce2ea5044fe842de50d30b51d72 schema:name doi
74 schema:value 10.1007/bf02535562
75 rdf:type schema:PropertyValue
76 N797bdfbbcc1f4b50b419c5c670bc661a schema:name Springer Nature - SN SciGraph project
77 rdf:type schema:Organization
78 N8248b2eb9c45417eb7a271036c7dff02 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
79 schema:name Phospholipid Ethers
80 rdf:type schema:DefinedTerm
81 N875c5f10713c474a8611b6fab27e4da9 rdf:first sg:person.01014522713.61
82 rdf:rest Ncdfa00abec7040a0a8b7699c219e877a
83 N91c94f050b7241d69f576578449a0955 rdf:first sg:person.01000145513.31
84 rdf:rest Nf6f9c46f09054fc0a25f50b9d5bd8961
85 N9d6946a26b9a400bacf49fb744baaae9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
86 schema:name Organophosphorus Compounds
87 rdf:type schema:DefinedTerm
88 Nb047b432f2b049c18d2618b4fff232f1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
89 schema:name Animals
90 rdf:type schema:DefinedTerm
91 Nc2f1e192dd3541c5b88db2b70f5feed3 schema:issueNumber 11
92 rdf:type schema:PublicationIssue
93 Ncdfa00abec7040a0a8b7699c219e877a rdf:first sg:person.01051322226.09
94 rdf:rest N3440d7a1858c4cb9a9a41f2ba3309499
95 Nd07bc60868654f4099e745994fa92077 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Rats, Inbred Strains
97 rdf:type schema:DefinedTerm
98 Nf6f9c46f09054fc0a25f50b9d5bd8961 rdf:first sg:person.01251326701.00
99 rdf:rest rdf:nil
100 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
101 schema:name Medical and Health Sciences
102 rdf:type schema:DefinedTerm
103 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
104 schema:name Clinical Sciences
105 rdf:type schema:DefinedTerm
106 sg:journal.1006395 schema:issn 0024-4201
107 1558-9307
108 schema:name Lipids
109 rdf:type schema:Periodical
110 sg:person.01000145513.31 schema:affiliation https://www.grid.ac/institutes/grid.424277.0
111 schema:familyName Pahlke
112 schema:givenName Wulf
113 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01000145513.31
114 rdf:type schema:Person
115 sg:person.01014522713.61 schema:affiliation https://www.grid.ac/institutes/grid.424277.0
116 schema:familyName Herrmann
117 schema:givenName Dieter B. J.
118 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01014522713.61
119 rdf:type schema:Person
120 sg:person.01051322226.09 schema:affiliation https://www.grid.ac/institutes/grid.424277.0
121 schema:familyName Besenfelder
122 schema:givenName Eberhard
123 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01051322226.09
124 rdf:type schema:Person
125 sg:person.01216213761.48 schema:affiliation https://www.grid.ac/institutes/grid.424277.0
126 schema:familyName Bicker
127 schema:givenName Uwe
128 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01216213761.48
129 rdf:type schema:Person
130 sg:person.01251326701.00 schema:affiliation https://www.grid.ac/institutes/grid.424277.0
131 schema:familyName Böhm
132 schema:givenName Erwin
133 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01251326701.00
134 rdf:type schema:Person
135 sg:pub.10.1007/bf00402775 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032283330
136 https://doi.org/10.1007/bf00402775
137 rdf:type schema:CreativeWork
138 sg:pub.10.1007/bf02535565 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042782497
139 https://doi.org/10.1007/bf02535565
140 rdf:type schema:CreativeWork
141 https://app.dimensions.ai/details/publication/pub.1079910651 schema:CreativeWork
142 https://app.dimensions.ai/details/publication/pub.1079998654 schema:CreativeWork
143 https://app.dimensions.ai/details/publication/pub.1080095269 schema:CreativeWork
144 https://app.dimensions.ai/details/publication/pub.1081236625 schema:CreativeWork
145 https://app.dimensions.ai/details/publication/pub.1082054654 schema:CreativeWork
146 https://doi.org/10.1016/0005-2760(78)90125-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1028202320
147 rdf:type schema:CreativeWork
148 https://doi.org/10.1016/0014-2964(80)90179-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050501128
149 rdf:type schema:CreativeWork
150 https://doi.org/10.1016/b978-0-12-730950-7.50010-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004665348
151 rdf:type schema:CreativeWork
152 https://doi.org/10.1093/jnci/75.3.423 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079999128
153 rdf:type schema:CreativeWork
154 https://doi.org/10.1093/jnci/78.6.1087 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079770530
155 rdf:type schema:CreativeWork
156 https://www.grid.ac/institutes/grid.424277.0 schema:alternateName Roche (Germany)
157 schema:name Department of Immunopharmacology and Cancer Research, Boehringer Mannheim GmbH, Sandhofer Strasse 116, 6800, Mannheim 31, Federal Republic of Germany
158 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...