Alkyl phosphocholines: Toxicity and anticancer properties View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1987-11

AUTHORS

C. Muschiol, M. R. Berger, B. Schuler, H. R. Scherf, F. T. Garzon, W. J. Zeller, C. Unger, H. J. Eibl, D. Schmähl

ABSTRACT

The study reports on the investigation of acute and subacute toxicity and on antineoplastic activity of hexadecylphosphocholine (HPC), the first compound of a new class of antineoplastic chemotherapeutics. In rats, the LD50 of HPC was 606 mumol/kg; the maximum tolerable dose over four weeks was 39 mumol/kg. Symptoms of toxicity were enteritis, spider cell activation in the liver, hemosiderosis in the spleen and reversible transaminase increase. The best therapeutic effect was observed on methylnitrosourea (MNU)-induced mammary carcinoma in the rat. Two transplantable mammary carcinomas in the rat and autochthonous benzo(a)pyrene-induced sarcomas exhibited low-grade sensitivity to HPC. The MXT mammary carcinoma of the mouse, the Walker 256 carcinosarcoma of the rat, and autochthonous acetoxymethylmethylnitrosamine-induced colonic tumors of the rat were not chemosensitive to HPC. More... »

PAGES

930-934

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf02535558

DOI

http://dx.doi.org/10.1007/bf02535558

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1023947179

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/3444388


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