Metabolism of ether phospholipids and analogs in neoplastic cells View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1987-11

AUTHORS

E. A. M. Fleer, C. Unger, D. -J. Kim, H. Eibl

ABSTRACT

The ether phospholipid 1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine (OM-GPC) is known to be a potent inhibitor of cell growth. Metabolic studies in both Raji and L1210 leukemic cells on OM-GPC, 3H-labeled in the methyl groups of the choline moiety, showed a (diacyl)-phosphatidylcholine as the only labeled metabolite. Since the formation of radiolabeled (diacyl)-phosphatidylcholine showed a direct correlation with cell death, we tested other lipid analogs. One of these compounds, hexadecylphosphocholine (He-PC), which was 3H-labeled in the methyl-choline groups, showed a formation of labeled (diacyl)-phosphatidylcholine similar to that found with OM-GPC. Again, there was a direct linear correlation between the formation of the labeled product and cell death. He-PC was found to be a potent cell toxin in in vitro experiments on cell cultures. However, analogs with an elongated phosphor to trimethylammonium distance showed no toxicity towards the cells in in vitro experiments. From the data, we conclude that the ether phospholipids are substrates for a phospholipase C or related enzyme. This substrate property may be responsible for the toxicity of the compounds in neoplastic cells. More... »

PAGES

856-861

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf02535544

DOI

http://dx.doi.org/10.1007/bf02535544

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1039344194

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/3444378


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