Ontology type: schema:ScholarlyArticle
1970-07
AUTHORSD. L. Turner, M. J. Silver, E. Baczynski, R. R. Holburn, S. F. Herb, F. E. Luddy
ABSTRACTSix different phosphatides were made by combination of phosphorus oxychloride and eithert-butyloxycarbonylaminoethanol or the phthalimidomethyl ester of anisyloxycarbonyl-L-serine with three different diglycerides. The diglycerides wererac-1,2-distearoloylglycerol,rac-1-stearoloyl-2-stearoylglycerol, andrac-1,2-di(9,10-methyleneoctadecanoyl) glycerol. The phosphatides were freed of protective groups by methods that did not cause rupture of the cyclopropane rings. The resulting phosphatides were purified by chromatography and evaluated for their effects on blood coagulation in vitro after solubilization with sodium desoxycholate. The phosphatidyl(distearoloyl)serine and the phosphatidyl di(9,10-methyleneoctadecanoyl) serine were as active as beef brain phosphatidylserine in the antithromboplastin test and the Hicks-Pitney test. The phosphatidyl(stearoloyl, stearoyl)serine was slightly less active in the Hicks-Pitney test. The phosphatidylethanolamines accelerated coagulation in the Hicks-Pitney test. The cyclopropane phosphatidylethanolamine was also tested in a test of prothrombin conversion using all purified components and was found to be active. The high activity of the cyclopropane phosphatidylserine is specially important because of its resistance to autoxidation. More... »
PAGES650-657
http://scigraph.springernature.com/pub.10.1007/bf02531344
DOIhttp://dx.doi.org/10.1007/bf02531344
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PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/5530522
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