Rapid separation of carrier-free inorganic and organic compounds of radioiodine and astatine by high-pressure liquid chromatography View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1974-03

AUTHORS

K. Rössler, W. Tornau, G. Stöcklin

ABSTRACT

The radioisotopes123I (T=13.3 h) and, potentially,211At(T=7.2 h) find increasing interest for radiopharmaceutical applications in diagnosis and therapy. They were produced via the122Te(α, 3n)13Xe(α+)13I and the209Bi(α, 2n)211At processes. Fast and efficient separations of carrier-free species obtained from target processing, as well as from classical or decay-induced synthesis were archieved by means of high-pressure ion-exchange and partition chromatography. Inorganic forms (X−, XO3−, At+) could be identified and separated on pretreated Aminex A 27 and A 7 resins, and biomolecules such as 5-halodeoxyuridines and-uracils on Aminex A 25 resins and Merckosorb Si 60 silica. The chromatographic methods can also be used for stability tests of radiopharmaceuticals in biochemical mixtures, notably physiological fluids. More... »

PAGES

199-209

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf02520862

DOI

http://dx.doi.org/10.1007/bf02520862

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1028978119


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