A novel ferrocenylalkylating reagent. Ferrocenylalkylation of imidazole and its derivatives View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1997-01

AUTHORS

V. V. Gumenyuk, Zh. V. Zhilina, Yu. S. Nekrasov, V. N. Babin, Yu. A. Belousov

ABSTRACT

Reactions of α-(1-benzotriazolyl)ethylferrocene (1) with 1,2,4-triazole, imidazole, benzimidazole, and edenine have been studied in the MeOH−HCl, MeOH, and AcOH systems. Compound 1 is a novel ferrocenylalkylating reagent which, unlike α-hydroxyalkylferrocenes, is capable of alkylating imidazole, benzimidazole (even in the absence of an acid catalyst), and adenine (regioselectively at the N(3) position). The antitumor activity discovered for ferrocenylalkylazoles of the type 1 may be attributed to the ability of such compounds to ferrocenylalkylate nucleic bases. More... »

PAGES

168-170

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf02495368

DOI

http://dx.doi.org/10.1007/bf02495368

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1042230496


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