Hepatitis C virus infection and chronic liver diseases after treatment of malignant disease in children: A multicenter study from the ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1998-08

AUTHORS

Isao Sekine, Hiroshi Dobashi, Kazuhiro Kogawa, Takahisa Hirota, Naoyuki Katano, Kiyoshi Kawakami, Shoichi Koizumi, Nobuyuki Hyakuna, Masahiko Nakayama, Youichi Takaue, Yasukazu Yamamura, Teruhisa Furuyama, Kenichi Nishikawa, Shigeru Ohta, Hiromichi Kubota, Junichi Mimaya, Yasuo Horikoshi, Takayoshi Tsuchiya, Takeo Takeda, Yoshio Hatae, Toshiaki Oka, Hiroshi Azuma, Takeo Fujimoto

ABSTRACT

We studied the prevalence of chronic liver diseases, including hepatitis C virus (HCV) and hepatitis B virus (HBV) infection, as late effects of therapeutic regimens against childhood malignancies in Japan. Patients were long-time survivors of acute lymphoblastic leukemia (ALL), acute non-lymphoblastic leukemia (ANLL), non-Hodgkin's lymphoma (NHL), neuroblastoma, and osteosarcoma, who had been treated and completed the Children's Cancer and Leukemia Study Group (CCLSG) protocols for more than 6 months at CCLSG participating institutions. The study was initially done in 1993, and as a follow-up study using a retrospective questionnaire in 1997. The overall prevalence of HCV infection in the 1993 study was 8.1% of 443 children. Among those long-term survivors in the 1993 study, 36 (8.1%) children (24 with ALL, 6 with ANLL, 2 with NHL, and 4 others) showed liver dysfunction. The details of the HCV-positive long-term survivors were 26 (13.3%) with ALL, 4 (12.9%) with ANLL, 1 (2%) with NHL, and 5 (3%) with others. The overall prevalence of HCV infection in the 1997 study at the same institutions was 0.6%. Only a slight reduction (5.6%) of HCV antibody positivity was noted in the 1997 follow-up study, while marked reduction (77.2%) of chronic liver disorders was noted during the same follow-up period in 623 children. The high frequency of HCV hepatitis among ALL children is thought to be related to frequent blood transfusions. The 1997 study is the lowest reported prevalence of HCV hepatitis among children with leukemia and malignant diseases. More... »

PAGES

247-252

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf02489841

DOI

http://dx.doi.org/10.1007/bf02489841

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1034439105


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