Interleukin-1α concentration in tumors as a risk factor for liver metastasis in gastric cancer View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1999-03

AUTHORS

Yoshitaka Furuya, Takashi Ichikura, Hidetaka Mochizuki

ABSTRACT

To investigate the relationship between the concentration of interleukin-1α (IL-1α) and liver metastasis in gastric cancer, the concentration of IL-1α was measured in homogenized tumor samples from 61 patients with gastric cancer. A significantly higher concentration of IL-1α was observed in tumors from patients with liver metastasis than in those from patients without liver metastasis; in differentiated type tumors than in undifferentiated type tumors; in tumors associated with moderate to severe venous invasion than in those associated with mild or no invasion; and in tumors with expansive or intermediate growth pattern (INFα, INFβ) than in those with an infiltrative pattern (IFNγ) by Student’st-test. Stepwise logistic regression revealed IL-1α, depth of invasion, venous invasion, and tumor size to be associated independently with liver metastasis. These findings led us to conclude that the IL-1α concentration was on eof the most useful determinants of liver metastasis among the various clinicopathologic characteristics. More... »

PAGES

288-289

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf02483025

DOI

http://dx.doi.org/10.1007/bf02483025

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1039773320

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/10192746


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