Epidural anesthesia during hysterectomy diminishes postoperative pain and urinary cortisol release View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1997-12

AUTHORS

Tomoko Yorozu, Hiroshi Morisaki, Masahiro Kondoh, Kazuo Tomizawa, Masato Satoh, Toshiyuki Shigematsu

ABSTRACT

PURPOSE: To examine the hypothesis that epidural anesthesia throughout lower abdominal surgery would depress both postoperative pain and cortisol release. METHODS: Forty adult patients undergoing abdominal total hysterectomy were studied. The patients were randomly assigned to two groups. Group G received general anesthesia alone (sevoflurane 1.5%-2.5%); group E received a combination of epidural anesthesia (1.5% mepivacaine) with a light plane of general anesthesia (sevoflurane<0.5%). Postoperative analgesia was obtained epidurally by patient-controlled analgesia. Postoperative pain at rest and during movement was assessed by a visual analogue scale (VAS) at 2, 24, and 48 h following surgery. The plasma concentration and urinary excretion of cortisol were measured during the perioperative period. RESULTS: VAS values were lower in group E than in group G during movement at 24h (4.6±0.5vs 6.1±0.4 cm). Urinary cortisol excretion on the first postoperative day was less in group E than in group G (192±34vs 480±120μg). CONCLUSIONS: Epidural blockade prior to surgical stimuli and throughout lower abdominal surgery reduces the postoperative dynamic pain and stress response. More... »

PAGES

260-264

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf02480741

DOI

http://dx.doi.org/10.1007/bf02480741

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1047722852

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28921063


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