A nonlinear three-compartiment model for the administration of 2′,3′-dideoxycytidine by using red blood cells as bioreactors View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1990-11

AUTHORS

F. Solimano, G. I. Bischi, M. Bianchi, L. Rossi, M. Magnani

ABSTRACT

A non-linear three-compartment model is proposed to describe a new strategy for the administration of 2′,3′-dideoxycytidine (ddCyd) in the treatment of HIV infections. The drug is injected after having been encapsulated in a non-diffusible form (ddCMP) into erythrocytes. Nummerical solutions show that by this treatment the highest ddCyd blood concentration is strongly reduced and in turn its toxicity, while long-lasting therapeutic effect is assured. The model is compared with experimental data in vitro. More... »

PAGES

785-796

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf02460809

DOI

http://dx.doi.org/10.1007/bf02460809

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1011175981


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