Effects of thyroid hormones on the transcription and structure of the malic enzyme gene in rat liver View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1996-08

AUTHORS

A. T. Adylova, Ya. Kh. Turakulov

ABSTRACT

Functionally different chromatin fractions have been isolated whose DNAs are used in hybridization with32P-labeled fragments of the malic enzyme gene. In thyroidectomized animals, homologs of the malic enzyme gene are found predominantly in the transcriptionally inactive chromatin fraction. In triiodothyronine-treated rats, the most intense hybridization signals are obtained from the chromatin fraction DNA hypersensitive to micrococcal nuclease and from DNA associated with the nuclear matrix. Thus, induction of the malic enzyme mRNA with triiodothyronine is attended by rearrangements at the higher levels of DNA packing. More... »

PAGES

832-834

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf02445162

DOI

http://dx.doi.org/10.1007/bf02445162

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1045474877


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