Effects of glucocorticoids and high density lipoproteins on activity of hepatocyte nuclei View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1999-12

AUTHORS

L. E. Panin, V. F. Maksimov, I. M. Korostyshevskaya

ABSTRACT

Combined exposure to high-density lipoproteins and glucocorticoids caused changes in the nucleus of rat hepatocytes. These changes most rapidly (within 10 min) appeared after stimulation of sinusoid cells and manifested themselves in enlargement of nucleoli, loosening of the fibrillar and accumulation of the granular components, and in an increase in nuclear membrane pore density. The increased binding and acridine orange enhanced red fluorescence attested to chromatin activation and enhanced gene expression. Resident macrophages play a key role in the realization of this mechanism. More... »

PAGES

1223-1225

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf02434823

DOI

http://dx.doi.org/10.1007/bf02434823

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1018441125


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