The bialaphos biosynthetic genes ofStreptomyces hygroscopicus: Molecular cloning and characterization of the gene cluster View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1986-10

AUTHORS

Takeshi Murakami, Hiroyuki Anzai, Satoshi Imai, Atsuyuki Satoh, Kozo Nagaoka, Charles J. Thompson

ABSTRACT

We have isolated and studied the organization ofStreptomyces hygroscopicus genes responsible for the biosynthesis of the antibiotic herbicide bialaphos. Bialaphos production genes were cloned from genomic DNA using a plasmid vector (pIJ702). Three plasmids were isolated which restored productivity toS. hygroscopicus mutants blocked at different steps of the biosynthetic pathway. Subcloning experiments using other nonproducing mutants showed that four additional bialaphos production genes were also contained on these plasmids. A gene conferring resistance to bialaphos, which was independently cloned using the plasmid vector pIJ61, and an antibiotic-sensitive host (S. lividans), was also linked to the production genes. Cosmids were isolated which defined the location of these genes in a 16 kb cluster. More... »

PAGES

42-53

Journal

TITLE

Molecular Genetics and Genomics

ISSUE

1

VOLUME

205

Author Affiliations

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    DOI

    http://dx.doi.org/10.1007/bf02428031

    DIMENSIONS

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