The bialaphos biosynthetic genes ofStreptomyces hygroscopicus: Molecular cloning and characterization of the gene cluster View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1986-10

AUTHORS

Takeshi Murakami, Hiroyuki Anzai, Satoshi Imai, Atsuyuki Satoh, Kozo Nagaoka, Charles J. Thompson

ABSTRACT

We have isolated and studied the organization ofStreptomyces hygroscopicus genes responsible for the biosynthesis of the antibiotic herbicide bialaphos. Bialaphos production genes were cloned from genomic DNA using a plasmid vector (pIJ702). Three plasmids were isolated which restored productivity toS. hygroscopicus mutants blocked at different steps of the biosynthetic pathway. Subcloning experiments using other nonproducing mutants showed that four additional bialaphos production genes were also contained on these plasmids. A gene conferring resistance to bialaphos, which was independently cloned using the plasmid vector pIJ61, and an antibiotic-sensitive host (S. lividans), was also linked to the production genes. Cosmids were isolated which defined the location of these genes in a 16 kb cluster. More... »

PAGES

42-53

References to SciGraph publications

Journal

TITLE

Molecular Genetics and Genomics

ISSUE

1

VOLUME

205

Author Affiliations

Related Patents

  • Homologous Recombination Mediated Transgene Deletion In Plant Cells
  • Compositions And Methods For Plant Transformation And Regeneration
  • Fertile Transgenic Maize Plants Containing A Gene Encoding The Pat Protein
  • Homologous Recombination-Mediated Transgene Alterations In Plants
  • Method Of Plant Breeding
  • Transgenic Monocots Plants With Increased Glycine-Betaine Content
  • Methods And Compositions For The Production Of Stably Transformed Fertile Monocot Plants And Cells Thereof
  • Fertile Transgenic Corn Plants
  • Plant Centromere Compositions
  • Plant-Functional Phosphinothricin Resistance Gene And Its Use
  • Compositions And Methods For Modifying Gene Expression Using The Promoter Of Ubiquitin Conjugating Protein Coding Gene Of Cotton Plants
  • Fertile Transgenic Corn Plants
  • Fertile Transgenic Zea Mays Plant Comprising Heterologous Dna Encoding Bacillus Thuringiensis Endotoxin
  • Methods And Compositions For Transformation And Regeneration Of Maize
  • High Lysine Fertile Transgenic Corn Plants
  • Glyphosate Resistant Maize Lines
  • Methods And Compositions For The Production Of Stably Transformed, Fertile Monocot Plants And Cells Thereof
  • Plants Modified With Mini-Chromosomes
  • Methods And Compositions For Transformation Of Cereals Using Cultured Shoot Meristematic Tissue
  • Method For Preparing Barley Green Regenerative Tissue
  • Methods And Compositions For The Production Of Stably Transformed Fertile Monocot Plants And Cells Thereof
  • Methods And Compositions For The Production Of Stably Transformed, Fertile Monocot Plants And Cells Thereof
  • Anthranilate Synthase Gene And Method Of Use Thereof For Conferring Tryptophan Overproduction
  • Plant-Functional Phosphinothricin Resistance Gene And Its Use
  • Production Of Proteins In Plant Seeds
  • Method For Preparing Fertile Transgenic Corn Plants
  • Methods And Compositions For Selective Regulation Of Protein Expression
  • Methods And Compositions For Selective Regulation Of Protein Expression
  • Homologous Recombination-Mediated Transgene Deletion In Plant Cells
  • Plant Cells Resistant To Glutamine Synthetase Inhibitors, Made By Genetic Engineering
  • Phosphinothricin-Resistant Gene And Its Use
  • Fertile Transgenic Corn Plants
  • Methods And Compositions For The Production Of Stably Transformed, Fertile Monocot Plants And Cells Thereof
  • Fertile Transgenic Corn Plants
  • Process Of Producing Fertile Transgenic Zea Mays Plants And Progeny Comprising A Gene Encoding Phosphinothricin Acetyl Transferase
  • Method For Preparing Fertile Transgenic Corn Plants
  • Plant Artificial Chromosome (Plac) Compositions And Methods
  • Methods And Compositions For The Production Of Stably Transformed, Fertile Monocot Plants And Cells Thereof
  • Isolation And Characterisation Of Genes Resistant To Anthracycline Antibiotics
  • Fertile Transgenic Corn Plants
  • Transgenic Maize With Increased Mannitol Content
  • Fertile Glyphosate-Resistant Transgenic Corn Plants
  • Anthranilate Synthase Gene And Method Of Use Thereof For Conferring Tryptophan Overproduction
  • Methods For Producing Hybrid Seed
  • Compositions And Methods For Plant Transformation And Regeneration
  • Homologous Recombination-Mediated Transgene Deletion In Plant Cells
  • Plant Centromere Compositions
  • Non Antibiotic Selectable Markers For Live Vaccines
  • Isolation And Characterisation Of Genes Resistant To Anthracycline Antibiotics
  • Insect Resistant Fertile Transgenic Corn Plants
  • Method For Altering The Nutritional Content Of Plant Seed
  • Phosphinothricin-Resistant Gene And Its Use
  • Centromere Sequences And Minichromosomes
  • Plants Modified With Mini-Chromosomes
  • Composition And Methods For Modifying Gene Expression Using The Promoter Of Ubiquitin Conjugating Protein Coding Gene Of Soybean Plants
  • Methods And Compositions For The Production Of Stably Transformed, Fertile Monocot Plants And Cells Thereof
  • Non-Reciprocal Recombination-Mediated Transgene Deletion In Transgenic Plants
  • Fertile Transgenic Corn Plants
  • Methods And Compositions For The Production Of Stably Transformed, Fertile Monocot Plants And Cells Thereof
  • Genetically Engineered Plant Cells And Plants Exhibiting Resistance To Glutamine Synthetase Inhibitors, Dna Fragments And Recombinants For Use In The Production Of Said Cells And Plants
  • Plants Modified With Mini-Chromosomes
  • Method For Plant Breeding
  • Sorghum Centromere Sequences And Minichromosomes
  • Plant Cells Resistant To Glutamine Synthetase Inhibitors, Made By Genetic Engineering
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/bf02428031

    DOI

    http://dx.doi.org/10.1007/bf02428031

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1034701767


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Genetics", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Meiji (Japan)", 
              "id": "https://www.grid.ac/institutes/grid.419680.2", 
              "name": [
                "Pharmaceutical Research Laboratories, Meiji Seika Kaisha, Ltd., Morooka-cho, Kohoku-ku, 222, Yokohama, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Murakami", 
            "givenName": "Takeshi", 
            "id": "sg:person.01050055022.42", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01050055022.42"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Meiji (Japan)", 
              "id": "https://www.grid.ac/institutes/grid.419680.2", 
              "name": [
                "Pharmaceutical Research Laboratories, Meiji Seika Kaisha, Ltd., Morooka-cho, Kohoku-ku, 222, Yokohama, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Anzai", 
            "givenName": "Hiroyuki", 
            "id": "sg:person.013153232211.21", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013153232211.21"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Meiji (Japan)", 
              "id": "https://www.grid.ac/institutes/grid.419680.2", 
              "name": [
                "Pharmaceutical Development Laboratories, Meiji Seika Kaisha Ltd., Horikawa-cho, Saiwai-ku, 210, Kawasaki, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Imai", 
            "givenName": "Satoshi", 
            "id": "sg:person.01056253571.32", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01056253571.32"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Meiji (Japan)", 
              "id": "https://www.grid.ac/institutes/grid.419680.2", 
              "name": [
                "Pharmaceutical Development Laboratories, Meiji Seika Kaisha Ltd., Horikawa-cho, Saiwai-ku, 210, Kawasaki, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Satoh", 
            "givenName": "Atsuyuki", 
            "id": "sg:person.012763134133.79", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012763134133.79"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Meiji (Japan)", 
              "id": "https://www.grid.ac/institutes/grid.419680.2", 
              "name": [
                "Pharmaceutical Research Laboratories, Meiji Seika Kaisha, Ltd., Morooka-cho, Kohoku-ku, 222, Yokohama, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nagaoka", 
            "givenName": "Kozo", 
            "id": "sg:person.01172502171.83", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01172502171.83"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Biogen S.A., P.O. Box, CH-1211, Geneva 24, Switzerland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Thompson", 
            "givenName": "Charles J.", 
            "id": "sg:person.01035607535.00", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01035607535.00"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/309462a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003208530", 
              "https://doi.org/10.1038/309462a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/hlca.19720550126", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007596454"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0378-1119(83)90037-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010091572"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0378-1119(83)90037-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010091572"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/10.21.6715", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016247343"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1574-6968.1985.tb01002.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017180405"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1574-6968.1985.tb01002.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017180405"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/314642a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026903987", 
              "https://doi.org/10.1038/314642a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf02425325", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029286084", 
              "https://doi.org/10.1007/bf02425325"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf02425325", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029286084", 
              "https://doi.org/10.1007/bf02425325"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/7.6.1513", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046335196"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00331065", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049715685", 
              "https://doi.org/10.1007/bf00331065"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0378-1119(80)90069-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051857651"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0378-1119(80)90069-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051857651"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1099/00221287-129-9-2703", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060364998"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1099/00221287-98-1-239", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060376067"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.216076", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062525115"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.7164/antibiotics.36.184", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1073631889"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.7164/antibiotics.36.429", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1073631935"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.7164/antibiotics.37.1505", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1073632128"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.7164/antibiotics.38.687", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1073632545"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.7164/antibiotics.39.128", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1073632650"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1075518052", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/j.1460-2075.1985.tb03866.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1079497548"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-3-642-68315-2_5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1081656921", 
              "https://doi.org/10.1007/978-3-642-68315-2_5"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "1986-10", 
        "datePublishedReg": "1986-10-01", 
        "description": "We have isolated and studied the organization ofStreptomyces hygroscopicus genes responsible for the biosynthesis of the antibiotic herbicide bialaphos. Bialaphos production genes were cloned from genomic DNA using a plasmid vector (pIJ702). Three plasmids were isolated which restored productivity toS. hygroscopicus mutants blocked at different steps of the biosynthetic pathway. Subcloning experiments using other nonproducing mutants showed that four additional bialaphos production genes were also contained on these plasmids. A gene conferring resistance to bialaphos, which was independently cloned using the plasmid vector pIJ61, and an antibiotic-sensitive host (S. lividans), was also linked to the production genes. Cosmids were isolated which defined the location of these genes in a 16 kb cluster.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1007/bf02428031", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1297380", 
            "issn": [
              "1617-4615", 
              "1432-1874"
            ], 
            "name": "Molecular Genetics and Genomics", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "205"
          }
        ], 
        "name": "The bialaphos biosynthetic genes ofStreptomyces hygroscopicus: Molecular cloning and characterization of the gene cluster", 
        "pagination": "42-53", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "a54e727001c823b06336e4175b4ccc32b5a1d3f58a84874f7e0811f49456a6cb"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/bf02428031"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1034701767"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/bf02428031", 
          "https://app.dimensions.ai/details/publication/pub.1034701767"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T13:32", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000370_0000000370/records_46760_00000001.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://link.springer.com/10.1007/BF02428031"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/bf02428031'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/bf02428031'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/bf02428031'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/bf02428031'


     

    This table displays all metadata directly associated to this object as RDF triples.

    166 TRIPLES      21 PREDICATES      48 URIs      19 LITERALS      7 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/bf02428031 schema:about anzsrc-for:06
    2 anzsrc-for:0604
    3 schema:author Nf9c1142e070040adb1528a4958914ec2
    4 schema:citation sg:pub.10.1007/978-3-642-68315-2_5
    5 sg:pub.10.1007/bf00331065
    6 sg:pub.10.1007/bf02425325
    7 sg:pub.10.1038/309462a0
    8 sg:pub.10.1038/314642a0
    9 https://app.dimensions.ai/details/publication/pub.1075518052
    10 https://doi.org/10.1002/hlca.19720550126
    11 https://doi.org/10.1002/j.1460-2075.1985.tb03866.x
    12 https://doi.org/10.1016/0378-1119(80)90069-4
    13 https://doi.org/10.1016/0378-1119(83)90037-9
    14 https://doi.org/10.1093/nar/10.21.6715
    15 https://doi.org/10.1093/nar/7.6.1513
    16 https://doi.org/10.1099/00221287-129-9-2703
    17 https://doi.org/10.1099/00221287-98-1-239
    18 https://doi.org/10.1111/j.1574-6968.1985.tb01002.x
    19 https://doi.org/10.1126/science.216076
    20 https://doi.org/10.7164/antibiotics.36.184
    21 https://doi.org/10.7164/antibiotics.36.429
    22 https://doi.org/10.7164/antibiotics.37.1505
    23 https://doi.org/10.7164/antibiotics.38.687
    24 https://doi.org/10.7164/antibiotics.39.128
    25 schema:datePublished 1986-10
    26 schema:datePublishedReg 1986-10-01
    27 schema:description We have isolated and studied the organization ofStreptomyces hygroscopicus genes responsible for the biosynthesis of the antibiotic herbicide bialaphos. Bialaphos production genes were cloned from genomic DNA using a plasmid vector (pIJ702). Three plasmids were isolated which restored productivity toS. hygroscopicus mutants blocked at different steps of the biosynthetic pathway. Subcloning experiments using other nonproducing mutants showed that four additional bialaphos production genes were also contained on these plasmids. A gene conferring resistance to bialaphos, which was independently cloned using the plasmid vector pIJ61, and an antibiotic-sensitive host (S. lividans), was also linked to the production genes. Cosmids were isolated which defined the location of these genes in a 16 kb cluster.
    28 schema:genre research_article
    29 schema:inLanguage en
    30 schema:isAccessibleForFree false
    31 schema:isPartOf N0741a6f3197a47238d5a7145c9c53f7a
    32 Na5223ef26a7a4ede86d58fc9e3d11bfa
    33 sg:journal.1297380
    34 schema:name The bialaphos biosynthetic genes ofStreptomyces hygroscopicus: Molecular cloning and characterization of the gene cluster
    35 schema:pagination 42-53
    36 schema:productId N77e5af41568a4dc5b48440d72704e4f4
    37 N7e9e2c7d8b464d358b3cacf6b8687ecf
    38 Nbecfcac7213c461aad3bb1b385978bdd
    39 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034701767
    40 https://doi.org/10.1007/bf02428031
    41 schema:sdDatePublished 2019-04-11T13:32
    42 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    43 schema:sdPublisher N17ae908f74fc4545905934db96b938df
    44 schema:url http://link.springer.com/10.1007/BF02428031
    45 sgo:license sg:explorer/license/
    46 sgo:sdDataset articles
    47 rdf:type schema:ScholarlyArticle
    48 N0741a6f3197a47238d5a7145c9c53f7a schema:issueNumber 1
    49 rdf:type schema:PublicationIssue
    50 N17ae908f74fc4545905934db96b938df schema:name Springer Nature - SN SciGraph project
    51 rdf:type schema:Organization
    52 N245e4abba47c4ece917fc213b0a79e59 rdf:first sg:person.01056253571.32
    53 rdf:rest Na26106bfeb4445e689d851c0da35adf6
    54 N66c0a766c4004cc486c265a350f518ac rdf:first sg:person.013153232211.21
    55 rdf:rest N245e4abba47c4ece917fc213b0a79e59
    56 N77e5af41568a4dc5b48440d72704e4f4 schema:name doi
    57 schema:value 10.1007/bf02428031
    58 rdf:type schema:PropertyValue
    59 N7c5f939cd721499d9dd30d87f13625f1 rdf:first sg:person.01035607535.00
    60 rdf:rest rdf:nil
    61 N7e9e2c7d8b464d358b3cacf6b8687ecf schema:name dimensions_id
    62 schema:value pub.1034701767
    63 rdf:type schema:PropertyValue
    64 Na08d3a6763a54d4888a749e71ca724f6 schema:name Biogen S.A., P.O. Box, CH-1211, Geneva 24, Switzerland
    65 rdf:type schema:Organization
    66 Na26106bfeb4445e689d851c0da35adf6 rdf:first sg:person.012763134133.79
    67 rdf:rest Nb1ae7034d6c34fb7bcaacc804aa764f1
    68 Na5223ef26a7a4ede86d58fc9e3d11bfa schema:volumeNumber 205
    69 rdf:type schema:PublicationVolume
    70 Nb1ae7034d6c34fb7bcaacc804aa764f1 rdf:first sg:person.01172502171.83
    71 rdf:rest N7c5f939cd721499d9dd30d87f13625f1
    72 Nbecfcac7213c461aad3bb1b385978bdd schema:name readcube_id
    73 schema:value a54e727001c823b06336e4175b4ccc32b5a1d3f58a84874f7e0811f49456a6cb
    74 rdf:type schema:PropertyValue
    75 Nf9c1142e070040adb1528a4958914ec2 rdf:first sg:person.01050055022.42
    76 rdf:rest N66c0a766c4004cc486c265a350f518ac
    77 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    78 schema:name Biological Sciences
    79 rdf:type schema:DefinedTerm
    80 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
    81 schema:name Genetics
    82 rdf:type schema:DefinedTerm
    83 sg:journal.1297380 schema:issn 1432-1874
    84 1617-4615
    85 schema:name Molecular Genetics and Genomics
    86 rdf:type schema:Periodical
    87 sg:person.01035607535.00 schema:affiliation Na08d3a6763a54d4888a749e71ca724f6
    88 schema:familyName Thompson
    89 schema:givenName Charles J.
    90 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01035607535.00
    91 rdf:type schema:Person
    92 sg:person.01050055022.42 schema:affiliation https://www.grid.ac/institutes/grid.419680.2
    93 schema:familyName Murakami
    94 schema:givenName Takeshi
    95 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01050055022.42
    96 rdf:type schema:Person
    97 sg:person.01056253571.32 schema:affiliation https://www.grid.ac/institutes/grid.419680.2
    98 schema:familyName Imai
    99 schema:givenName Satoshi
    100 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01056253571.32
    101 rdf:type schema:Person
    102 sg:person.01172502171.83 schema:affiliation https://www.grid.ac/institutes/grid.419680.2
    103 schema:familyName Nagaoka
    104 schema:givenName Kozo
    105 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01172502171.83
    106 rdf:type schema:Person
    107 sg:person.012763134133.79 schema:affiliation https://www.grid.ac/institutes/grid.419680.2
    108 schema:familyName Satoh
    109 schema:givenName Atsuyuki
    110 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012763134133.79
    111 rdf:type schema:Person
    112 sg:person.013153232211.21 schema:affiliation https://www.grid.ac/institutes/grid.419680.2
    113 schema:familyName Anzai
    114 schema:givenName Hiroyuki
    115 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013153232211.21
    116 rdf:type schema:Person
    117 sg:pub.10.1007/978-3-642-68315-2_5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1081656921
    118 https://doi.org/10.1007/978-3-642-68315-2_5
    119 rdf:type schema:CreativeWork
    120 sg:pub.10.1007/bf00331065 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049715685
    121 https://doi.org/10.1007/bf00331065
    122 rdf:type schema:CreativeWork
    123 sg:pub.10.1007/bf02425325 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029286084
    124 https://doi.org/10.1007/bf02425325
    125 rdf:type schema:CreativeWork
    126 sg:pub.10.1038/309462a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003208530
    127 https://doi.org/10.1038/309462a0
    128 rdf:type schema:CreativeWork
    129 sg:pub.10.1038/314642a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026903987
    130 https://doi.org/10.1038/314642a0
    131 rdf:type schema:CreativeWork
    132 https://app.dimensions.ai/details/publication/pub.1075518052 schema:CreativeWork
    133 https://doi.org/10.1002/hlca.19720550126 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007596454
    134 rdf:type schema:CreativeWork
    135 https://doi.org/10.1002/j.1460-2075.1985.tb03866.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1079497548
    136 rdf:type schema:CreativeWork
    137 https://doi.org/10.1016/0378-1119(80)90069-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051857651
    138 rdf:type schema:CreativeWork
    139 https://doi.org/10.1016/0378-1119(83)90037-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010091572
    140 rdf:type schema:CreativeWork
    141 https://doi.org/10.1093/nar/10.21.6715 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016247343
    142 rdf:type schema:CreativeWork
    143 https://doi.org/10.1093/nar/7.6.1513 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046335196
    144 rdf:type schema:CreativeWork
    145 https://doi.org/10.1099/00221287-129-9-2703 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060364998
    146 rdf:type schema:CreativeWork
    147 https://doi.org/10.1099/00221287-98-1-239 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060376067
    148 rdf:type schema:CreativeWork
    149 https://doi.org/10.1111/j.1574-6968.1985.tb01002.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1017180405
    150 rdf:type schema:CreativeWork
    151 https://doi.org/10.1126/science.216076 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062525115
    152 rdf:type schema:CreativeWork
    153 https://doi.org/10.7164/antibiotics.36.184 schema:sameAs https://app.dimensions.ai/details/publication/pub.1073631889
    154 rdf:type schema:CreativeWork
    155 https://doi.org/10.7164/antibiotics.36.429 schema:sameAs https://app.dimensions.ai/details/publication/pub.1073631935
    156 rdf:type schema:CreativeWork
    157 https://doi.org/10.7164/antibiotics.37.1505 schema:sameAs https://app.dimensions.ai/details/publication/pub.1073632128
    158 rdf:type schema:CreativeWork
    159 https://doi.org/10.7164/antibiotics.38.687 schema:sameAs https://app.dimensions.ai/details/publication/pub.1073632545
    160 rdf:type schema:CreativeWork
    161 https://doi.org/10.7164/antibiotics.39.128 schema:sameAs https://app.dimensions.ai/details/publication/pub.1073632650
    162 rdf:type schema:CreativeWork
    163 https://www.grid.ac/institutes/grid.419680.2 schema:alternateName Meiji (Japan)
    164 schema:name Pharmaceutical Development Laboratories, Meiji Seika Kaisha Ltd., Horikawa-cho, Saiwai-ku, 210, Kawasaki, Japan
    165 Pharmaceutical Research Laboratories, Meiji Seika Kaisha, Ltd., Morooka-cho, Kohoku-ku, 222, Yokohama, Japan
    166 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...