Cyclotron production, radiochemical separation and quality control of platinum radiotracers for toxicological studies View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1998-10

AUTHORS

M. Bonardi, C. Birattari, M. Gallorini, F. Groppi, D. Arginelli, L. Gini

ABSTRACT

The increasing concentration of Pt, Pd and Rh in the environment is mainly due to the release of these elements from the catalytic converters of the motorvehicles. This situation makes it necessary to carry out metallotoxicological experiments on both cell cultures and laboratory animals, in order to assess their impact on living organisms after a Long Term and Low Level Exposure (LLE). Both nuclear reactionsnatIr(p,xn) andnatOs(α,xn) were investigated in the energy range up to 45 MeV for protons and 38 MeV for alpha-particles, in order to optimize the irradiation parameters for the production of188,189,191Pt. Several sets of thin- and thick-target excitation functions were determined experimentally by cyclotron irradiation at both Milano and Ispra cyclotrons. This paper reports the irradiation parameters studied and adopted and two radiochemical procedures for the separation of radio-Pt from an Os target, as well as from ruthenium, iridium and gold impurities. These procedures were used to obtain very high specific activity Pt radionuclides in No Carrier Added (NCA) form. Radionuclidic, radiochemical and chemical purity measurements were carred out by the use of several techniques like ψ-spectrometry, ion-exchange radio-chromatography, atomic absorption spectrometry and neutron activation analysis. More... »

PAGES

159-164

References to SciGraph publications

  • 1981-03. The short-lived radioisotope production program at manchester in JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
  • 1992-07. Preparation of high specific activity radiotracers for radioanalytical studies in JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
  • 1995-05. Analytical and radioanalytical quality control in high specific activity radiotracer preparation in JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
  • 1992-07. Application of radiotracers with high specific radioactivity to metallotoxicological studies in JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/bf02386335

    DOI

    http://dx.doi.org/10.1007/bf02386335

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1038640729


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/03", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Chemical Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0301", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Analytical Chemistry", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "LASA, University and INFN Milano, via F.lli Cervi 201, 20090 Segrate, Milano, Italy", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "LASA, University and INFN Milano, via F.lli Cervi 201, 20090 Segrate, Milano, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bonardi", 
            "givenName": "M.", 
            "id": "sg:person.01224717334.18", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01224717334.18"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "LASA, University and INFN Milano, via F.lli Cervi 201, 20090 Segrate, Milano, Italy", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "LASA, University and INFN Milano, via F.lli Cervi 201, 20090 Segrate, Milano, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Birattari", 
            "givenName": "C.", 
            "id": "sg:person.0621402734.36", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0621402734.36"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "CNR, Centre for Radiochemistry and Activation Analysis and INFN, Pavia, Italy", 
              "id": "http://www.grid.ac/institutes/grid.5326.2", 
              "name": [
                "CNR, Centre for Radiochemistry and Activation Analysis and INFN, Pavia, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Gallorini", 
            "givenName": "M.", 
            "id": "sg:person.01024133111.31", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01024133111.31"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "LASA, University and INFN Milano, via F.lli Cervi 201, 20090 Segrate, Milano, Italy", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "LASA, University and INFN Milano, via F.lli Cervi 201, 20090 Segrate, Milano, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Groppi", 
            "givenName": "F.", 
            "id": "sg:person.01215241655.97", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215241655.97"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "LASA, University and INFN Milano, via F.lli Cervi 201, 20090 Segrate, Milano, Italy", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "LASA, University and INFN Milano, via F.lli Cervi 201, 20090 Segrate, Milano, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Arginelli", 
            "givenName": "D.", 
            "id": "sg:person.01312051464.49", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01312051464.49"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "LASA, University and INFN Milano, via F.lli Cervi 201, 20090 Segrate, Milano, Italy", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "LASA, University and INFN Milano, via F.lli Cervi 201, 20090 Segrate, Milano, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Gini", 
            "givenName": "L.", 
            "id": "sg:person.01046601233.03", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01046601233.03"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1007/bf02037125", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035887062", 
              "https://doi.org/10.1007/bf02037125"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf02518355", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035643888", 
              "https://doi.org/10.1007/bf02518355"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf02041915", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040541080", 
              "https://doi.org/10.1007/bf02041915"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf02037130", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040452311", 
              "https://doi.org/10.1007/bf02037130"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "1998-10", 
        "datePublishedReg": "1998-10-01", 
        "description": "The increasing concentration of Pt, Pd and Rh in the environment is mainly due to the release of these elements from the catalytic converters of the motorvehicles. This situation makes it necessary to carry out metallotoxicological experiments on both cell cultures and laboratory animals, in order to assess their impact on living organisms after a Long Term and Low Level Exposure (LLE). Both nuclear reactionsnatIr(p,xn) andnatOs(\u03b1,xn) were investigated in the energy range up to 45 MeV for protons and 38 MeV for alpha-particles, in order to optimize the irradiation parameters for the production of188,189,191Pt. Several sets of thin- and thick-target excitation functions were determined experimentally by cyclotron irradiation at both Milano and Ispra cyclotrons. This paper reports the irradiation parameters studied and adopted and two radiochemical procedures for the separation of radio-Pt from an Os target, as well as from ruthenium, iridium and gold impurities. These procedures were used to obtain very high specific activity Pt radionuclides in No Carrier Added (NCA) form. Radionuclidic, radiochemical and chemical purity measurements were carred out by the use of several techniques like \u03c8-spectrometry, ion-exchange radio-chromatography, atomic absorption spectrometry and neutron activation analysis.", 
        "genre": "article", 
        "id": "sg:pub.10.1007/bf02386335", 
        "inLanguage": "en", 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1094634", 
            "issn": [
              "0236-5731", 
              "1588-2780"
            ], 
            "name": "Journal of Radioanalytical and Nuclear Chemistry", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1-2", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "236"
          }
        ], 
        "keywords": [
          "atomic absorption spectrometry", 
          "thick-target excitation functions", 
          "absorption spectrometry", 
          "radiochemical separation", 
          "neutron activation analysis", 
          "concentration of Pt", 
          "radiochemical procedure", 
          "cyclotron irradiation", 
          "spectrometry", 
          "purity measurements", 
          "Pt", 
          "catalytic converter", 
          "activation analysis", 
          "gold impurities", 
          "irradiation parameters", 
          "separation", 
          "ruthenium", 
          "radionuclidic", 
          "toxicological studies", 
          "iridium", 
          "cyclotron production", 
          "protons", 
          "Rh", 
          "Pd", 
          "quality control", 
          "low-level exposure", 
          "impurities", 
          "energy range", 
          "irradiation", 
          "carriers", 
          "concentration", 
          "release", 
          "range", 
          "radiotracer", 
          "level exposure", 
          "measurements", 
          "parameters", 
          "order", 
          "technique", 
          "procedure", 
          "production", 
          "cell cultures", 
          "form", 
          "experiments", 
          "cyclotron", 
          "analysis", 
          "organisms", 
          "environment", 
          "MeV", 
          "use", 
          "target", 
          "exposure", 
          "elements", 
          "study", 
          "terms", 
          "excitation functions", 
          "function", 
          "laboratory animals", 
          "set", 
          "impact", 
          "control", 
          "paper", 
          "long term", 
          "Milano", 
          "culture", 
          "converter", 
          "situation", 
          "animals"
        ], 
        "name": "Cyclotron production, radiochemical separation and quality control of platinum radiotracers for toxicological studies", 
        "pagination": "159-164", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1038640729"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/bf02386335"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/bf02386335", 
          "https://app.dimensions.ai/details/publication/pub.1038640729"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-06-01T22:01", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20220601/entities/gbq_results/article/article_278.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1007/bf02386335"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/bf02386335'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/bf02386335'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/bf02386335'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/bf02386335'


     

    This table displays all metadata directly associated to this object as RDF triples.

    180 TRIPLES      22 PREDICATES      98 URIs      86 LITERALS      6 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/bf02386335 schema:about anzsrc-for:03
    2 anzsrc-for:0301
    3 schema:author N2db5dcdf17494b8a8f5c027a8042c9f4
    4 schema:citation sg:pub.10.1007/bf02037125
    5 sg:pub.10.1007/bf02037130
    6 sg:pub.10.1007/bf02041915
    7 sg:pub.10.1007/bf02518355
    8 schema:datePublished 1998-10
    9 schema:datePublishedReg 1998-10-01
    10 schema:description The increasing concentration of Pt, Pd and Rh in the environment is mainly due to the release of these elements from the catalytic converters of the motorvehicles. This situation makes it necessary to carry out metallotoxicological experiments on both cell cultures and laboratory animals, in order to assess their impact on living organisms after a Long Term and Low Level Exposure (LLE). Both nuclear reactionsnatIr(p,xn) andnatOs(α,xn) were investigated in the energy range up to 45 MeV for protons and 38 MeV for alpha-particles, in order to optimize the irradiation parameters for the production of188,189,191Pt. Several sets of thin- and thick-target excitation functions were determined experimentally by cyclotron irradiation at both Milano and Ispra cyclotrons. This paper reports the irradiation parameters studied and adopted and two radiochemical procedures for the separation of radio-Pt from an Os target, as well as from ruthenium, iridium and gold impurities. These procedures were used to obtain very high specific activity Pt radionuclides in No Carrier Added (NCA) form. Radionuclidic, radiochemical and chemical purity measurements were carred out by the use of several techniques like ψ-spectrometry, ion-exchange radio-chromatography, atomic absorption spectrometry and neutron activation analysis.
    11 schema:genre article
    12 schema:inLanguage en
    13 schema:isAccessibleForFree false
    14 schema:isPartOf N297e75e145c04c55ac3736ec31a3b9cc
    15 Nca4cf43d93234c8ea164bad22892cc3b
    16 sg:journal.1094634
    17 schema:keywords MeV
    18 Milano
    19 Pd
    20 Pt
    21 Rh
    22 absorption spectrometry
    23 activation analysis
    24 analysis
    25 animals
    26 atomic absorption spectrometry
    27 carriers
    28 catalytic converter
    29 cell cultures
    30 concentration
    31 concentration of Pt
    32 control
    33 converter
    34 culture
    35 cyclotron
    36 cyclotron irradiation
    37 cyclotron production
    38 elements
    39 energy range
    40 environment
    41 excitation functions
    42 experiments
    43 exposure
    44 form
    45 function
    46 gold impurities
    47 impact
    48 impurities
    49 iridium
    50 irradiation
    51 irradiation parameters
    52 laboratory animals
    53 level exposure
    54 long term
    55 low-level exposure
    56 measurements
    57 neutron activation analysis
    58 order
    59 organisms
    60 paper
    61 parameters
    62 procedure
    63 production
    64 protons
    65 purity measurements
    66 quality control
    67 radiochemical procedure
    68 radiochemical separation
    69 radionuclidic
    70 radiotracer
    71 range
    72 release
    73 ruthenium
    74 separation
    75 set
    76 situation
    77 spectrometry
    78 study
    79 target
    80 technique
    81 terms
    82 thick-target excitation functions
    83 toxicological studies
    84 use
    85 schema:name Cyclotron production, radiochemical separation and quality control of platinum radiotracers for toxicological studies
    86 schema:pagination 159-164
    87 schema:productId N6db40bfe204b4c51ac16c960da883d4e
    88 Nba3ff796ee2241809c47a03e03b80fd5
    89 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038640729
    90 https://doi.org/10.1007/bf02386335
    91 schema:sdDatePublished 2022-06-01T22:01
    92 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    93 schema:sdPublisher Ne8f5ea4f697a47838c5d1b267db7084a
    94 schema:url https://doi.org/10.1007/bf02386335
    95 sgo:license sg:explorer/license/
    96 sgo:sdDataset articles
    97 rdf:type schema:ScholarlyArticle
    98 N297e75e145c04c55ac3736ec31a3b9cc schema:volumeNumber 236
    99 rdf:type schema:PublicationVolume
    100 N2db5dcdf17494b8a8f5c027a8042c9f4 rdf:first sg:person.01224717334.18
    101 rdf:rest N4e17b790d745482ea06d70630c359b6a
    102 N4e17b790d745482ea06d70630c359b6a rdf:first sg:person.0621402734.36
    103 rdf:rest Ne8b22a3bb97b4a5a8b56c912aa86e96a
    104 N6db40bfe204b4c51ac16c960da883d4e schema:name dimensions_id
    105 schema:value pub.1038640729
    106 rdf:type schema:PropertyValue
    107 Nba3ff796ee2241809c47a03e03b80fd5 schema:name doi
    108 schema:value 10.1007/bf02386335
    109 rdf:type schema:PropertyValue
    110 Nca4cf43d93234c8ea164bad22892cc3b schema:issueNumber 1-2
    111 rdf:type schema:PublicationIssue
    112 Nd88799b434ec496e9a20da3fa2eabc65 rdf:first sg:person.01046601233.03
    113 rdf:rest rdf:nil
    114 Ndb95c1dcf1dc45e8b19f488b408f05c3 rdf:first sg:person.01312051464.49
    115 rdf:rest Nd88799b434ec496e9a20da3fa2eabc65
    116 Ne80f50cae6e0466da6fb1d27392fe694 rdf:first sg:person.01215241655.97
    117 rdf:rest Ndb95c1dcf1dc45e8b19f488b408f05c3
    118 Ne8b22a3bb97b4a5a8b56c912aa86e96a rdf:first sg:person.01024133111.31
    119 rdf:rest Ne80f50cae6e0466da6fb1d27392fe694
    120 Ne8f5ea4f697a47838c5d1b267db7084a schema:name Springer Nature - SN SciGraph project
    121 rdf:type schema:Organization
    122 anzsrc-for:03 schema:inDefinedTermSet anzsrc-for:
    123 schema:name Chemical Sciences
    124 rdf:type schema:DefinedTerm
    125 anzsrc-for:0301 schema:inDefinedTermSet anzsrc-for:
    126 schema:name Analytical Chemistry
    127 rdf:type schema:DefinedTerm
    128 sg:journal.1094634 schema:issn 0236-5731
    129 1588-2780
    130 schema:name Journal of Radioanalytical and Nuclear Chemistry
    131 schema:publisher Springer Nature
    132 rdf:type schema:Periodical
    133 sg:person.01024133111.31 schema:affiliation grid-institutes:grid.5326.2
    134 schema:familyName Gallorini
    135 schema:givenName M.
    136 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01024133111.31
    137 rdf:type schema:Person
    138 sg:person.01046601233.03 schema:affiliation grid-institutes:None
    139 schema:familyName Gini
    140 schema:givenName L.
    141 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01046601233.03
    142 rdf:type schema:Person
    143 sg:person.01215241655.97 schema:affiliation grid-institutes:None
    144 schema:familyName Groppi
    145 schema:givenName F.
    146 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215241655.97
    147 rdf:type schema:Person
    148 sg:person.01224717334.18 schema:affiliation grid-institutes:None
    149 schema:familyName Bonardi
    150 schema:givenName M.
    151 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01224717334.18
    152 rdf:type schema:Person
    153 sg:person.01312051464.49 schema:affiliation grid-institutes:None
    154 schema:familyName Arginelli
    155 schema:givenName D.
    156 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01312051464.49
    157 rdf:type schema:Person
    158 sg:person.0621402734.36 schema:affiliation grid-institutes:None
    159 schema:familyName Birattari
    160 schema:givenName C.
    161 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0621402734.36
    162 rdf:type schema:Person
    163 sg:pub.10.1007/bf02037125 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035887062
    164 https://doi.org/10.1007/bf02037125
    165 rdf:type schema:CreativeWork
    166 sg:pub.10.1007/bf02037130 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040452311
    167 https://doi.org/10.1007/bf02037130
    168 rdf:type schema:CreativeWork
    169 sg:pub.10.1007/bf02041915 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040541080
    170 https://doi.org/10.1007/bf02041915
    171 rdf:type schema:CreativeWork
    172 sg:pub.10.1007/bf02518355 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035643888
    173 https://doi.org/10.1007/bf02518355
    174 rdf:type schema:CreativeWork
    175 grid-institutes:None schema:alternateName LASA, University and INFN Milano, via F.lli Cervi 201, 20090 Segrate, Milano, Italy
    176 schema:name LASA, University and INFN Milano, via F.lli Cervi 201, 20090 Segrate, Milano, Italy
    177 rdf:type schema:Organization
    178 grid-institutes:grid.5326.2 schema:alternateName CNR, Centre for Radiochemistry and Activation Analysis and INFN, Pavia, Italy
    179 schema:name CNR, Centre for Radiochemistry and Activation Analysis and INFN, Pavia, Italy
    180 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...