A high abundance of PTH-related protein in human cerebrospinal fluid View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1994-02

AUTHORS

Koshi Natsui, Chohei Shigeno, Hiroaki Kohno, Toru Yamamoto, Ryuichi Kasai, Kiyoshi Tanaka, Takao Yamamuro, Kazuwa Nakao, Junji Konishi

ABSTRACT

Parathyroid hormone-related protein (PTHrP) has diverse actions other than causing hypercalcemia. Evidences are accumulating to suggest the roles of PTHrP in the central nervous system (CNS). We measured PTHrP concentration in human cerebrospinal fluid (CSF), which was higher than that in plasma. PTHrP in CSF was bioactive in stimulating cAMP production in cultured osteoblastic cells. Our deta, together with previous report that area and cell-specific mRNA expression of PTHrP and PTH/PTHrP receptor, suggest fundamental roles of PTHrP in CNS. More... »

PAGES

s207-s209

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf02375704

DOI

http://dx.doi.org/10.1007/bf02375704

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1034886547


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