Intestinal and extraintestinal complications of Crohn's disease: Predictors and cumulative probability of complications View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1994-10

AUTHORS

Kazuhiro Maeda, Mitsuo Okada, Tsuneyoshi Yao, Toshihiro Sakurai, Mitsuo Iida, Tadahiko Fuchigami, Kazuhiko Yoshinaga, Kensaburou Imamura, Yasuhiro Okada, Kiyoto Sakamoto, Hirokazu Date

ABSTRACT

Of 238 patients with Crohn's disease seen at our clinics from April 1973 to August 1988, 203 patients were selected for this study, since they fulfilled the following criteria: they had been followed up for more than 6 months as outpatients or had been treated as inpatients for more than 1 month. They were studied to elucidate: (a) the different types and indidence of various complications, (b) the factors related to complications present at the time of diagnosis, (c) predictors of new complications arising after diagnosis, and (d) the cumulative incidence of complications occurring during the course of the disease from the times of onset and diagnosis. Of the intestinal complications, perianal fistula was most common (33%), followed by strictures with dilatations of the proximal bowel (21%), and internal fistula (14%). Of the extraintestinal complications, menstrual disturbance was the most common (18% of the female patients), followed by arthritis (10%), and aphthous stomatitis (10%). As for the factors influencing complications present at the time of diagnosis, the pattern of bowel involvement was significantly correlated with the presence of intestinal stricuture, while the erythrocyte sedimentation rate was significantly correlated with the presence of perianal fistula. A significant predictor of new complications arising after diagnosis was the general well-beling of patients at the time of diagnosis. Patients who, at diagnosis, already have complications such as stricture, absominal abscess, internal or external fistula, massive hemorrhage, and free perforation or anal lesions are more likely to develop new complications in addition to those present at diagnosis, compared with patients without any complications at diagnosis (P=0.055). More... »

PAGES

577-582

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf02365438

DOI

http://dx.doi.org/10.1007/bf02365438

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1051703757

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/8000504


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