Expression of adhesion molecules and HLA-DR by macrophages and dendritic cells in aphthoid lesions of Crohn's disease: An immunocytochemical study View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1994-06

AUTHORS

Kimitomo Morise, Takeo Yamaguchi, Atsuo Kuroiwa, Kazuhiro Kanayama, Toshihiro Matsuura, Masataka Shinoda, Hitoshi Yamamoto, Yoh Horiuchi, Atsushi Furusawa, Hiroaki Iwase, Kazuo Kusugami, Hiroshi Nagura

ABSTRACT

The phenotypes and ultrastructure of macrophages and dendritic cells in aphthoid lesions of the colon were immunocytochemically observed in patients with Crohn's disease. Biopsy specimens were endoscopically obtained from both aphthoid and advanced lesions in Crohn's disease patients. Biopsy specimens obtained from patients with infectious colitis and from normal individuals served as controls. Aphthoid lesions contained densely aggregated CD68+ macrophages, which were surrounded by numerous ID-1+ dendritic cells. In the normal controls and infectious colitis patients, however, a few scattered CD68+ macrophages and ID-1+ dendritic cells were noted beneath the surface epithelium. CD3+ lymphocytes were significantly increased in both aphthoid and advanced lesions of Crohn's disease, but the CD4/CD8 ratio was similar in all groups studied. The double immunoperoxidase staining method revealed that both CD68+ macrophages and ID-1+ dendritic cells in the aphthoid lesions simultaneously expressed ICAM-1 and HLA-DR antigens. Electronmicroscopic observation revealed that CD68+ macrophages had numerous vesicles and lysosomal granules and few projections, and that ID-1+ dendritic cells had appreciable cytoplasmic protrusions with a few vacuoles. These findings suggested that the colonic mucosa in Crohn's disease contained two types of macrophage/dendritic cells in the same lineage that expressed intercellular adhesion molecules and class-II MHC antigens. It also appeared that the aphthoid lesions of Crohn's disease featured an increase in macrophages and dendritic cells consistent with immunological activation. More... »

PAGES

257-264

References to SciGraph publications

  • 1989-09. Interdigitating cell sarcoma (ICS) in VIRCHOWS ARCHIV A PATHOLOGICAL ANATOMY AND HISTOPATHOLOGY
  • 1979-08. Crohn’s disease in Japan in JOURNAL OF GASTROENTEROLOGY
  • 1989-04. Cotransfection of ICAM-1 and HLA-DR reconstitutes human antigen-presenting cell function in mouse L cells in NATURE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/bf02358363

    DOI

    http://dx.doi.org/10.1007/bf02358363

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1005667252

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/7914801


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    67 immunoperoxidase staining method
    68 increase
    69 individuals
    70 infectious colitis
    71 intercellular adhesion molecule
    72 lesions
    73 lineages
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    75 lysosomal granules
    76 macrophages
    77 macrophages/dendritic cells
    78 method
    79 molecules
    80 mucosa
    81 normal controls
    82 normal individuals
    83 numerous vesicles
    84 observations
    85 patients
    86 phenotype
    87 projections
    88 protrusion
    89 ratio
    90 same lineage
    91 specimens
    92 staining method
    93 study
    94 surface epithelium
    95 types
    96 ultrastructure
    97 ultrastructure of macrophages
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