Distribution of desmin filaments in the myocardium of the failing heart View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1994-12

AUTHORS

Michiaki Hiroe, Masato Tanaka, Toshio Nishikawa, Shigeru Ishiyama, Makoto Nagata, Takeshi Kasajima, Fumiaki Marumo

ABSTRACT

Desmin filaments specific for muscle cells, normally localized at the Z band level and intercalated discs, may play an important role in maintaining the structure of the cardiomyocytes. By immunoelectron microscopy, we examined the distribution of desmin in endomyocardial biopsy samples of 10 patients with dilated cardiomyopathy. We found an increased number of desmin filaments characterized by a disordered arrangement in the myocytes. Desmin immunolabeling was transversely and longitudinally distributed at the Z band level and near the intercalated discs within the cytoplasm of the myocytes lacking myofilaments. These data suggest that desmin filaments could play a role in the defence mechanisms of the cardiomyocytes threatened by stress overloading in the diseased human heart. More... »

PAGES

246-248

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf02349666

DOI

http://dx.doi.org/10.1007/bf02349666

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1004774391


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