A relationship between GC content and coding-sequence length View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1996-09

AUTHORS

José L. Oliver, Antonio Marín

ABSTRACT

Since base composition of translational stop codons (TAG, TAA, and TGA) is biased toward a low G+C content, a differential density for these termination signals is expected in random DNA sequences of different base compositions. The expected length of reading frames (DNA segments of sense codons flanked by in-phase stop codons) in random sequences is thus a function of GC content. The analysis of DNA sequences from several genome databases stratified according to GC content reveals that the longest coding sequences-exons in vertebrates and genes in prokaryotes-are GC-rich, while the shortest ones are GC-poor. Exon lengthening in GC-rich vertebrate regions does not result, however, in longer vertebrate proteins, perhaps because of the lower number of exons in the genes located in these regions. The effects on coding-sequence lengths constitute a new evolutionary meaning for compositional variations in DNA GC content. More... »

PAGES

216-223

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf02338829

DOI

http://dx.doi.org/10.1007/bf02338829

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1044629710

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/8703087


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