Intrapleural photodynamic therapy: Results of a phase I trial View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1994-01

AUTHORS

Harvey I. Pass, Thomas F. DeLaney, Zelig Tochner, Paul E. Smith, Barbara K. Temeck, Helen W. Pogrebniak, Karen C. Kranda, Angelo Russo, Walter S. Friauf, John W. Cole, James B. Mitchell, Gunter Thomas

ABSTRACT

Background: The management of pleural neoplasms, specifically mesothelioma, remains difficult. We performed a phase I trial in 54 patients with isolated hemithorax pleural malignancy to determine (a) the feasibility of intraoperative, intrapleural photodynamic therapy after debulking surgery; (b) the influence of light dose/sensitizer interval on postoperative morbidity in order to define the photodynamic therapy (PDT) maximal tolerated dose (MTD); and (c) whether first order dosimetry could be applied to this complex geometry.Methods: Cohorts of three patients were given escalating intraoperative light doses of 15–35 J/cm2 48 h after i.v. delivery of 2.0 mg/kg Photofrin II (Quadra Logic Technologies, Vancouver, British Columbia, Canada), and then escalating light doses of 30–32.5 J/cm2 after a 24-h sensitizer/operation interval. Twelve patients could not be debulked to the prerequisite 5 mm residual tumor thickness. The remaining 42 patients underwent 19 modified pleuropneumonectomies, five lobectomy-pleurectomies, and 18 pleurectomies. Intrapleural PDT was delivered using 630 nm light from two argon pump-dye lasers, and real-time and cumulative light doses were monitored using seven uniquely designed, computer-interfaced photodiodes.Results: There was one 30-day mortality from intraoperative hemorrhage. In the 48-h sensitizer/operation group (n=33), possible PDT-related complications included an empyema with late hemorrhage in one of three patients at 17.5 J/cm2 and a bronchopleural fistula at 35 J/cm2. At each of these light doses, three additional patients were treated without complication. Two patients subjected to 24-h sensitizer dosing and 32.5 J/cm2 developed esophageal perforations after pleuropneumonectomy at identical sites. The MTD was declared as 30 J/cm2 light with a 24-h dosing interval when none of the six patients (three original, three repeat) at that level developed toxicity.Conclusions: These data demonstrate that resection and intrapleural PDT can be performed safely with currently available sensitizers and lasers. Phase II and III trials are now warranted at this MTD in a homogeneous population of patients with pleural malignancies. More... »

PAGES

28-37

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf02303538

DOI

http://dx.doi.org/10.1007/bf02303538

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1003120273

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/7834425


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Combined Modality Therapy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mesothelioma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Photochemotherapy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pleural Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Survival Rate", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Thoracic Oncology Section, Surgery Branch, National Cancer Institute, National Institutes of Health, Building 10, Room 2B07, 20892, Bethesda, MD, USA", 
          "id": "http://www.grid.ac/institutes/grid.48336.3a", 
          "name": [
            "Thoracic Oncology Section, Surgery Branch, National Cancer Institute, National Institutes of Health, Building 10, Room 2B07, 20892, Bethesda, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pass", 
        "givenName": "Harvey I.", 
        "id": "sg:person.0763326335.92", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0763326335.92"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Radiation Oncology Branch and Experimental Phototherapy Section, National Cancer Institute, National Institutes of Health, USA", 
          "id": "http://www.grid.ac/institutes/grid.48336.3a", 
          "name": [
            "Radiation Oncology Branch and Experimental Phototherapy Section, National Cancer Institute, National Institutes of Health, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "DeLaney", 
        "givenName": "Thomas F.", 
        "id": "sg:person.011105000337.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011105000337.49"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Radiation Oncology Branch and Experimental Phototherapy Section, National Cancer Institute, National Institutes of Health, USA", 
          "id": "http://www.grid.ac/institutes/grid.48336.3a", 
          "name": [
            "Radiation Oncology Branch and Experimental Phototherapy Section, National Cancer Institute, National Institutes of Health, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tochner", 
        "givenName": "Zelig", 
        "id": "sg:person.053570030.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.053570030.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Biomedical Engineering and Instrumentation Program, National Center for Research Resources, National Institutes of Health, Bethesda, Maryland, USA", 
          "id": "http://www.grid.ac/institutes/grid.94365.3d", 
          "name": [
            "Biomedical Engineering and Instrumentation Program, National Center for Research Resources, National Institutes of Health, Bethesda, Maryland, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Smith", 
        "givenName": "Paul E.", 
        "id": "sg:person.012561650317.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012561650317.13"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Thoracic Oncology Section, Surgery Branch, National Cancer Institute, National Institutes of Health, Building 10, Room 2B07, 20892, Bethesda, MD, USA", 
          "id": "http://www.grid.ac/institutes/grid.48336.3a", 
          "name": [
            "Thoracic Oncology Section, Surgery Branch, National Cancer Institute, National Institutes of Health, Building 10, Room 2B07, 20892, Bethesda, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Temeck", 
        "givenName": "Barbara K.", 
        "id": "sg:person.01306041342.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01306041342.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Thoracic Oncology Section, Surgery Branch, National Cancer Institute, National Institutes of Health, Building 10, Room 2B07, 20892, Bethesda, MD, USA", 
          "id": "http://www.grid.ac/institutes/grid.48336.3a", 
          "name": [
            "Thoracic Oncology Section, Surgery Branch, National Cancer Institute, National Institutes of Health, Building 10, Room 2B07, 20892, Bethesda, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pogrebniak", 
        "givenName": "Helen W.", 
        "id": "sg:person.01223477320.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01223477320.37"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Thoracic Oncology Section, Surgery Branch, National Cancer Institute, National Institutes of Health, Building 10, Room 2B07, 20892, Bethesda, MD, USA", 
          "id": "http://www.grid.ac/institutes/grid.48336.3a", 
          "name": [
            "Thoracic Oncology Section, Surgery Branch, National Cancer Institute, National Institutes of Health, Building 10, Room 2B07, 20892, Bethesda, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kranda", 
        "givenName": "Karen C.", 
        "id": "sg:person.01032321717.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01032321717.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Radiation Oncology Branch and Experimental Phototherapy Section, National Cancer Institute, National Institutes of Health, USA", 
          "id": "http://www.grid.ac/institutes/grid.48336.3a", 
          "name": [
            "Radiation Oncology Branch and Experimental Phototherapy Section, National Cancer Institute, National Institutes of Health, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Russo", 
        "givenName": "Angelo", 
        "id": "sg:person.01046205245.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01046205245.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Biomedical Engineering and Instrumentation Program, National Center for Research Resources, National Institutes of Health, Bethesda, Maryland, USA", 
          "id": "http://www.grid.ac/institutes/grid.94365.3d", 
          "name": [
            "Biomedical Engineering and Instrumentation Program, National Center for Research Resources, National Institutes of Health, Bethesda, Maryland, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Friauf", 
        "givenName": "Walter S.", 
        "id": "sg:person.014401452607.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014401452607.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Biomedical Engineering and Instrumentation Program, National Center for Research Resources, National Institutes of Health, Bethesda, Maryland, USA", 
          "id": "http://www.grid.ac/institutes/grid.94365.3d", 
          "name": [
            "Biomedical Engineering and Instrumentation Program, National Center for Research Resources, National Institutes of Health, Bethesda, Maryland, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cole", 
        "givenName": "John W.", 
        "id": "sg:person.01211242634.96", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01211242634.96"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Radiation Oncology Branch and Experimental Phototherapy Section, National Cancer Institute, National Institutes of Health, USA", 
          "id": "http://www.grid.ac/institutes/grid.48336.3a", 
          "name": [
            "Radiation Oncology Branch and Experimental Phototherapy Section, National Cancer Institute, National Institutes of Health, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mitchell", 
        "givenName": "James B.", 
        "id": "sg:person.014251525642.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014251525642.48"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Radiation Oncology Branch and Experimental Phototherapy Section, National Cancer Institute, National Institutes of Health, USA", 
          "id": "http://www.grid.ac/institutes/grid.48336.3a", 
          "name": [
            "Radiation Oncology Branch and Experimental Phototherapy Section, National Cancer Institute, National Institutes of Health, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Thomas", 
        "givenName": "Gunter", 
        "id": "sg:person.07550762252.57", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07550762252.57"
        ], 
        "type": "Person"
      }
    ], 
    "datePublished": "1994-01", 
    "datePublishedReg": "1994-01-01", 
    "description": "Background: The management of pleural neoplasms, specifically mesothelioma, remains difficult. We performed a phase I trial in 54 patients with isolated hemithorax pleural malignancy to determine (a) the feasibility of intraoperative, intrapleural photodynamic therapy after debulking surgery; (b) the influence of light dose/sensitizer interval on postoperative morbidity in order to define the photodynamic therapy (PDT) maximal tolerated dose (MTD); and (c) whether first order dosimetry could be applied to this complex geometry.Methods: Cohorts of three patients were given escalating intraoperative light doses of 15\u201335 J/cm2 48 h after i.v. delivery of 2.0 mg/kg Photofrin II (Quadra Logic Technologies, Vancouver, British Columbia, Canada), and then escalating light doses of 30\u201332.5 J/cm2 after a 24-h sensitizer/operation interval. Twelve patients could not be debulked to the prerequisite 5 mm residual tumor thickness. The remaining 42 patients underwent 19 modified pleuropneumonectomies, five lobectomy-pleurectomies, and 18 pleurectomies. Intrapleural PDT was delivered using 630 nm light from two argon pump-dye lasers, and real-time and cumulative light doses were monitored using seven uniquely designed, computer-interfaced photodiodes.Results: There was one 30-day mortality from intraoperative hemorrhage. In the 48-h sensitizer/operation group (n=33), possible PDT-related complications included an empyema with late hemorrhage in one of three patients at 17.5 J/cm2 and a bronchopleural fistula at 35 J/cm2. At each of these light doses, three additional patients were treated without complication. Two patients subjected to 24-h sensitizer dosing and 32.5 J/cm2 developed esophageal perforations after pleuropneumonectomy at identical sites. The MTD was declared as 30 J/cm2 light with a 24-h dosing interval when none of the six patients (three original, three repeat) at that level developed toxicity.Conclusions: These data demonstrate that resection and intrapleural PDT can be performed safely with currently available sensitizers and lasers. Phase II and III trials are now warranted at this MTD in a homogeneous population of patients with pleural malignancies.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/bf02303538", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1105545", 
        "issn": [
          "1068-9265", 
          "1534-4681"
        ], 
        "name": "Annals of Surgical Oncology", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "1"
      }
    ], 
    "keywords": [
      "phase I trial", 
      "pleural malignancy", 
      "light doses", 
      "residual tumor thickness", 
      "intrapleural photodynamic therapy", 
      "postoperative morbidity", 
      "late hemorrhage", 
      "esophageal perforation", 
      "intraoperative hemorrhage", 
      "bronchopleural fistula", 
      "additional patients", 
      "tumor thickness", 
      "operation group", 
      "pleural neoplasms", 
      "patients", 
      "doses", 
      "trials", 
      "pleuropneumonectomy", 
      "phase II", 
      "hemorrhage", 
      "complications", 
      "Photofrin II", 
      "malignancy", 
      "MTD", 
      "photodynamic therapy", 
      "homogeneous population", 
      "cm2 light", 
      "intervals", 
      "morbidity", 
      "pleurectomy", 
      "empyema", 
      "resection", 
      "fistula", 
      "surgery", 
      "neoplasms", 
      "mesothelioma", 
      "therapy", 
      "PDT", 
      "cohort", 
      "mortality", 
      "perforation", 
      "dose", 
      "available sensitizers", 
      "toxicity", 
      "maximal", 
      "identical sites", 
      "delivery", 
      "group", 
      "population", 
      "sensitizers", 
      "management", 
      "levels", 
      "dosimetry", 
      "operation interval", 
      "data", 
      "sites", 
      "feasibility", 
      "prerequisite", 
      "results", 
      "light", 
      "influence", 
      "thickness", 
      "cm2", 
      "laser", 
      "order", 
      "geometry", 
      "complex geometries", 
      "photodiodes", 
      "I trial", 
      "hemithorax pleural malignancy", 
      "light dose/sensitizer interval", 
      "dose/sensitizer interval", 
      "sensitizer interval", 
      "photodynamic therapy (PDT) maximal", 
      "therapy (PDT) maximal", 
      "first order dosimetry", 
      "order dosimetry", 
      "intraoperative light doses", 
      "cm2 48 h", 
      "sensitizer/operation interval", 
      "Intrapleural PDT", 
      "argon pump-dye lasers", 
      "pump-dye lasers", 
      "cumulative light doses", 
      "computer-interfaced photodiodes", 
      "sensitizer/operation group", 
      "possible PDT-related complications", 
      "PDT-related complications"
    ], 
    "name": "Intrapleural photodynamic therapy: Results of a phase I trial", 
    "pagination": "28-37", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1003120273"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/bf02303538"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "7834425"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/bf02303538", 
      "https://app.dimensions.ai/details/publication/pub.1003120273"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2021-12-01T19:07", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20211201/entities/gbq_results/article/article_231.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/bf02303538"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/bf02303538'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/bf02303538'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/bf02303538'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/bf02303538'


 

This table displays all metadata directly associated to this object as RDF triples.

276 TRIPLES      21 PREDICATES      126 URIs      118 LITERALS      18 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/bf02303538 schema:about N001abcb2e9f34809832b4d7203422b77
2 N02065721f7504fc2b49f26f748e15072
3 N0d88f46c8edf4baaabf08d0b892c194c
4 N1f30128bb46b4f3799f5a2794a5c02eb
5 N2724ff04aeef435bbcb6f5517174315d
6 N36dc6d246fd54662bcfbeb3f64b66426
7 N37e5f540701e4d03a549237a56280740
8 N5d3b66ae5739483b87a066e652bce193
9 N76f5db4b37d14786a1f03c9476a077f3
10 N818a8d534a064459ab81fea8a22f86e5
11 Nc4d73a35717f4f18b230692deeb39391
12 anzsrc-for:11
13 anzsrc-for:1103
14 schema:author N683fb731776a4c69a7fb2bc40b668250
15 schema:datePublished 1994-01
16 schema:datePublishedReg 1994-01-01
17 schema:description Background: The management of pleural neoplasms, specifically mesothelioma, remains difficult. We performed a phase I trial in 54 patients with isolated hemithorax pleural malignancy to determine (a) the feasibility of intraoperative, intrapleural photodynamic therapy after debulking surgery; (b) the influence of light dose/sensitizer interval on postoperative morbidity in order to define the photodynamic therapy (PDT) maximal tolerated dose (MTD); and (c) whether first order dosimetry could be applied to this complex geometry.Methods: Cohorts of three patients were given escalating intraoperative light doses of 15–35 J/cm2 48 h after i.v. delivery of 2.0 mg/kg Photofrin II (Quadra Logic Technologies, Vancouver, British Columbia, Canada), and then escalating light doses of 30–32.5 J/cm2 after a 24-h sensitizer/operation interval. Twelve patients could not be debulked to the prerequisite 5 mm residual tumor thickness. The remaining 42 patients underwent 19 modified pleuropneumonectomies, five lobectomy-pleurectomies, and 18 pleurectomies. Intrapleural PDT was delivered using 630 nm light from two argon pump-dye lasers, and real-time and cumulative light doses were monitored using seven uniquely designed, computer-interfaced photodiodes.Results: There was one 30-day mortality from intraoperative hemorrhage. In the 48-h sensitizer/operation group (n=33), possible PDT-related complications included an empyema with late hemorrhage in one of three patients at 17.5 J/cm2 and a bronchopleural fistula at 35 J/cm2. At each of these light doses, three additional patients were treated without complication. Two patients subjected to 24-h sensitizer dosing and 32.5 J/cm2 developed esophageal perforations after pleuropneumonectomy at identical sites. The MTD was declared as 30 J/cm2 light with a 24-h dosing interval when none of the six patients (three original, three repeat) at that level developed toxicity.Conclusions: These data demonstrate that resection and intrapleural PDT can be performed safely with currently available sensitizers and lasers. Phase II and III trials are now warranted at this MTD in a homogeneous population of patients with pleural malignancies.
18 schema:genre article
19 schema:inLanguage en
20 schema:isAccessibleForFree false
21 schema:isPartOf N38760f2e451840189c45fc703e4f09a8
22 Nfd45616365ec492b9037c8c069207f8d
23 sg:journal.1105545
24 schema:keywords I trial
25 Intrapleural PDT
26 MTD
27 PDT
28 PDT-related complications
29 Photofrin II
30 additional patients
31 argon pump-dye lasers
32 available sensitizers
33 bronchopleural fistula
34 cm2
35 cm2 48 h
36 cm2 light
37 cohort
38 complex geometries
39 complications
40 computer-interfaced photodiodes
41 cumulative light doses
42 data
43 delivery
44 dose
45 dose/sensitizer interval
46 doses
47 dosimetry
48 empyema
49 esophageal perforation
50 feasibility
51 first order dosimetry
52 fistula
53 geometry
54 group
55 hemithorax pleural malignancy
56 hemorrhage
57 homogeneous population
58 identical sites
59 influence
60 intervals
61 intraoperative hemorrhage
62 intraoperative light doses
63 intrapleural photodynamic therapy
64 laser
65 late hemorrhage
66 levels
67 light
68 light dose/sensitizer interval
69 light doses
70 malignancy
71 management
72 maximal
73 mesothelioma
74 morbidity
75 mortality
76 neoplasms
77 operation group
78 operation interval
79 order
80 order dosimetry
81 patients
82 perforation
83 phase I trial
84 phase II
85 photodiodes
86 photodynamic therapy
87 photodynamic therapy (PDT) maximal
88 pleural malignancy
89 pleural neoplasms
90 pleurectomy
91 pleuropneumonectomy
92 population
93 possible PDT-related complications
94 postoperative morbidity
95 prerequisite
96 pump-dye lasers
97 resection
98 residual tumor thickness
99 results
100 sensitizer interval
101 sensitizer/operation group
102 sensitizer/operation interval
103 sensitizers
104 sites
105 surgery
106 therapy
107 therapy (PDT) maximal
108 thickness
109 toxicity
110 trials
111 tumor thickness
112 schema:name Intrapleural photodynamic therapy: Results of a phase I trial
113 schema:pagination 28-37
114 schema:productId N09e9ddb697404ef0bc5b0b38b437737f
115 Na7b68cab218040f5afb2792309daf949
116 Nf9b15be1a2464152962937d59b4ed080
117 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003120273
118 https://doi.org/10.1007/bf02303538
119 schema:sdDatePublished 2021-12-01T19:07
120 schema:sdLicense https://scigraph.springernature.com/explorer/license/
121 schema:sdPublisher Nfe3b0746075c4529adf142131f4c6d58
122 schema:url https://doi.org/10.1007/bf02303538
123 sgo:license sg:explorer/license/
124 sgo:sdDataset articles
125 rdf:type schema:ScholarlyArticle
126 N001abcb2e9f34809832b4d7203422b77 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Adult
128 rdf:type schema:DefinedTerm
129 N02065721f7504fc2b49f26f748e15072 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Humans
131 rdf:type schema:DefinedTerm
132 N09e9ddb697404ef0bc5b0b38b437737f schema:name dimensions_id
133 schema:value pub.1003120273
134 rdf:type schema:PropertyValue
135 N0d2bf3dc546145e18b22c3e30c86f80b rdf:first sg:person.01046205245.21
136 rdf:rest Nca815392fdf3432e9e83acb4c85a2de9
137 N0d88f46c8edf4baaabf08d0b892c194c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Survival Rate
139 rdf:type schema:DefinedTerm
140 N0dd76758f13a42aab306565ba80ac81f rdf:first sg:person.053570030.30
141 rdf:rest N47d925163fd6438890650138a01827c3
142 N1f30128bb46b4f3799f5a2794a5c02eb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Mesothelioma
144 rdf:type schema:DefinedTerm
145 N2724ff04aeef435bbcb6f5517174315d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Photochemotherapy
147 rdf:type schema:DefinedTerm
148 N36dc6d246fd54662bcfbeb3f64b66426 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Aged
150 rdf:type schema:DefinedTerm
151 N37e5f540701e4d03a549237a56280740 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Pleural Neoplasms
153 rdf:type schema:DefinedTerm
154 N38760f2e451840189c45fc703e4f09a8 schema:issueNumber 1
155 rdf:type schema:PublicationIssue
156 N40d749fe19c843ea821dd0aa132081ff rdf:first sg:person.01032321717.09
157 rdf:rest N0d2bf3dc546145e18b22c3e30c86f80b
158 N47d925163fd6438890650138a01827c3 rdf:first sg:person.012561650317.13
159 rdf:rest Nd78eef6f17e14f7f9b8220a465c2c155
160 N5a2732232268444ca24128caf52f351b rdf:first sg:person.07550762252.57
161 rdf:rest rdf:nil
162 N5d3b66ae5739483b87a066e652bce193 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Male
164 rdf:type schema:DefinedTerm
165 N683fb731776a4c69a7fb2bc40b668250 rdf:first sg:person.0763326335.92
166 rdf:rest N7514df8bf28546e3bf9773b3864fe9d0
167 N7514df8bf28546e3bf9773b3864fe9d0 rdf:first sg:person.011105000337.49
168 rdf:rest N0dd76758f13a42aab306565ba80ac81f
169 N76f5db4b37d14786a1f03c9476a077f3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name Combined Modality Therapy
171 rdf:type schema:DefinedTerm
172 N818a8d534a064459ab81fea8a22f86e5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name Middle Aged
174 rdf:type schema:DefinedTerm
175 N96701c0d954746afa7373aadbc0eceed rdf:first sg:person.01223477320.37
176 rdf:rest N40d749fe19c843ea821dd0aa132081ff
177 Na01c6175610c4c7f974a2fc2416f0843 rdf:first sg:person.014251525642.48
178 rdf:rest N5a2732232268444ca24128caf52f351b
179 Na7b68cab218040f5afb2792309daf949 schema:name pubmed_id
180 schema:value 7834425
181 rdf:type schema:PropertyValue
182 Nc4d73a35717f4f18b230692deeb39391 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
183 schema:name Female
184 rdf:type schema:DefinedTerm
185 Nca815392fdf3432e9e83acb4c85a2de9 rdf:first sg:person.014401452607.09
186 rdf:rest Ne1ed771c43cb4a9eac59205107760633
187 Nd78eef6f17e14f7f9b8220a465c2c155 rdf:first sg:person.01306041342.14
188 rdf:rest N96701c0d954746afa7373aadbc0eceed
189 Ne1ed771c43cb4a9eac59205107760633 rdf:first sg:person.01211242634.96
190 rdf:rest Na01c6175610c4c7f974a2fc2416f0843
191 Nf9b15be1a2464152962937d59b4ed080 schema:name doi
192 schema:value 10.1007/bf02303538
193 rdf:type schema:PropertyValue
194 Nfd45616365ec492b9037c8c069207f8d schema:volumeNumber 1
195 rdf:type schema:PublicationVolume
196 Nfe3b0746075c4529adf142131f4c6d58 schema:name Springer Nature - SN SciGraph project
197 rdf:type schema:Organization
198 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
199 schema:name Medical and Health Sciences
200 rdf:type schema:DefinedTerm
201 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
202 schema:name Clinical Sciences
203 rdf:type schema:DefinedTerm
204 sg:journal.1105545 schema:issn 1068-9265
205 1534-4681
206 schema:name Annals of Surgical Oncology
207 schema:publisher Springer Nature
208 rdf:type schema:Periodical
209 sg:person.01032321717.09 schema:affiliation grid-institutes:grid.48336.3a
210 schema:familyName Kranda
211 schema:givenName Karen C.
212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01032321717.09
213 rdf:type schema:Person
214 sg:person.01046205245.21 schema:affiliation grid-institutes:grid.48336.3a
215 schema:familyName Russo
216 schema:givenName Angelo
217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01046205245.21
218 rdf:type schema:Person
219 sg:person.011105000337.49 schema:affiliation grid-institutes:grid.48336.3a
220 schema:familyName DeLaney
221 schema:givenName Thomas F.
222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011105000337.49
223 rdf:type schema:Person
224 sg:person.01211242634.96 schema:affiliation grid-institutes:grid.94365.3d
225 schema:familyName Cole
226 schema:givenName John W.
227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01211242634.96
228 rdf:type schema:Person
229 sg:person.01223477320.37 schema:affiliation grid-institutes:grid.48336.3a
230 schema:familyName Pogrebniak
231 schema:givenName Helen W.
232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01223477320.37
233 rdf:type schema:Person
234 sg:person.012561650317.13 schema:affiliation grid-institutes:grid.94365.3d
235 schema:familyName Smith
236 schema:givenName Paul E.
237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012561650317.13
238 rdf:type schema:Person
239 sg:person.01306041342.14 schema:affiliation grid-institutes:grid.48336.3a
240 schema:familyName Temeck
241 schema:givenName Barbara K.
242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01306041342.14
243 rdf:type schema:Person
244 sg:person.014251525642.48 schema:affiliation grid-institutes:grid.48336.3a
245 schema:familyName Mitchell
246 schema:givenName James B.
247 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014251525642.48
248 rdf:type schema:Person
249 sg:person.014401452607.09 schema:affiliation grid-institutes:grid.94365.3d
250 schema:familyName Friauf
251 schema:givenName Walter S.
252 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014401452607.09
253 rdf:type schema:Person
254 sg:person.053570030.30 schema:affiliation grid-institutes:grid.48336.3a
255 schema:familyName Tochner
256 schema:givenName Zelig
257 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.053570030.30
258 rdf:type schema:Person
259 sg:person.07550762252.57 schema:affiliation grid-institutes:grid.48336.3a
260 schema:familyName Thomas
261 schema:givenName Gunter
262 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07550762252.57
263 rdf:type schema:Person
264 sg:person.0763326335.92 schema:affiliation grid-institutes:grid.48336.3a
265 schema:familyName Pass
266 schema:givenName Harvey I.
267 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0763326335.92
268 rdf:type schema:Person
269 grid-institutes:grid.48336.3a schema:alternateName Radiation Oncology Branch and Experimental Phototherapy Section, National Cancer Institute, National Institutes of Health, USA
270 Thoracic Oncology Section, Surgery Branch, National Cancer Institute, National Institutes of Health, Building 10, Room 2B07, 20892, Bethesda, MD, USA
271 schema:name Radiation Oncology Branch and Experimental Phototherapy Section, National Cancer Institute, National Institutes of Health, USA
272 Thoracic Oncology Section, Surgery Branch, National Cancer Institute, National Institutes of Health, Building 10, Room 2B07, 20892, Bethesda, MD, USA
273 rdf:type schema:Organization
274 grid-institutes:grid.94365.3d schema:alternateName Biomedical Engineering and Instrumentation Program, National Center for Research Resources, National Institutes of Health, Bethesda, Maryland, USA
275 schema:name Biomedical Engineering and Instrumentation Program, National Center for Research Resources, National Institutes of Health, Bethesda, Maryland, USA
276 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...