Urinary excretion of ethylenethiourea and kidney morphology in rats after continuous oral exposure to nabam or ethylenethiourea View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1991-07

AUTHORS

Päivi Kurttio, Kai Savolainen, Anita Naukkarinen, Veli-Matti Kosma, Leena Tuomisto, Ilkka Penttilä, Jukka Jolkkonen

ABSTRACT

Nabam, an ethylenebisdithiocarbamate (EBDC), is an agricultural fungicide. Ethylenethiourea (ETU), widely used in the rubber industry, is a degradation and byproduct of metabolism and of storage and production of EBDCs. Kidney function and morphology, and urinary excretion of ETU, were studied in rats exposed to nabam or ETU in drinking water for 28 days. The concentrations of nabam in drinking water were 0, 50, 100 or 200 mg/l, and of ETU 0, 100, 200 or 300 mg/l. Both compounds decreased body weight gain but did not significantly affect urinary sodium, potassium, glucose, or protein excretion, or urinary osmolality. Urinary vasopressin was also unaltered after exposure to nabam or ETU. High doses of ETU resulted in ultrastructural alterations in epithelial cells of renal proximal tubuli. ETU was excreted in urine after exposure to both nabam and ETU. There seemed to be a threshold dose of ETU below which no ultrastructural alterations in kidney occurred. More... »

PAGES

381-385

References to SciGraph publications

  • 1986. Ethylenethiourea and Nabam Induced Alterations of Function and Morphology of Thyroid Gland in Rats in TOXIC INTERFACES OF NEURONES, SMOKE AND GENES
  • 1976-11. Metabolic fate of ethylenethiourea in pregnant rats in BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
  • 1974-02. The excretion of ethylenethiourea by rat and guinea pig in BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
  • 1971-06. Untersuchungen zum Metabolismus der fungiciden Äthylen-bis-dithiocarbamate Maneb, Zineb und NabamV. Mitteilung Zur Toxikologie der Abbauprodukte in EUROPEAN FOOD RESEARCH AND TECHNOLOGY
  • 1989. Ethylenethiourea as an Indicator of Exposure to Ethylenebisdithiocarbamate Fungicides in BIOLOGICAL MONITORING OF EXPOSURE AND THE RESPONSE AT THE SUBCELLULAR LEVEL TO TOXIC SUBSTANCES
  • 1979-12. Examination of thein vivo metabolism of maneb and zineb to ethylenethiourea (ETU) in mice in BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/bf02284260

    DOI

    http://dx.doi.org/10.1007/bf02284260

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1007942074

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/1929852


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