Effects of aspirin, acetaminophen, and salicylamide on gastric mucosa of dogs View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1964-07

AUTHORS

J. J. Fishler

ABSTRACT

The effects of aspirin, acetaminophen, and salicylamide on the gastric mucosa of dogs were studied in a blind controlled experiment. Oral dosage ranged from a single 5-gr. dose up to 30 gr. per day for 10 days. Seven different dosage levels were tested. Aspirin, when given for more than one day, proved highly irritating in doses of 5–15 gr. b.i.d. With the higher dosage, widespread hemorrhage and ulceration of the gastric mucosa occurred after 3 and 6 days' administration. Irritation occurred but was less evident after 10 days' administration. In contrast, acetaminophen and salicylamide were essentially nonirritating. These drugs would seem to merit consideration in patients with gastrointestinal lesions or in those requiring more than occasional analgetic-antipyretic therapy. More... »

PAGES

465-470

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf02283917

DOI

http://dx.doi.org/10.1007/bf02283917

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1025365211

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/14180352


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