Determination of fosfomycin in human urine by capillary gas chromatography: Application to clinical pharmacokinetic studies View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1996-09

AUTHORS

M. C. Dios-Viéitez, M. M. Goñi, M. J. Renedo, D. Fos

ABSTRACT

A capillary gas chromatographic method for the determination of fosfomycin in human urine is described. After dilution of the sample and derivatization, analysis was on a HP-1 capillary column and a flame ionization detector was used to determine the bistrimethylsilyl derivative of fosfomycin. Response was linear in the range 50–5000 μg mL−1. The detection limit was about 10 μg mL−1. The within and between day coefficients of variation did not exceed 6%. The method was applied to the determination of fosfomycin in urine samples collected during clinical pharmacokinetic studies. More... »

PAGES

293-295

Journal

TITLE

Chromatographia

ISSUE

5-6

VOLUME

43

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf02270997

DOI

http://dx.doi.org/10.1007/bf02270997

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1003391807


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