Determination of doxycycline in small serum samples by liquid chromatography. Application to pharmacokinetical studies on small laboratory animals View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1993-05

AUTHORS

I. Gastearena, M. C. Dios-Viéitez, E. Segura, M. M. Goñi, M. J. Renedo, D. Fos

ABSTRACT

Several methods have been described for the analysis of doxycycline in serum which require at least 0.5 mL sample. The assay presented here requires small amounts of serum (0.1 mL) and shows good sensitivity. A Ultrabase C-18 column and mobile phase consisting of acetonitrile-bidistilled water (28∶72) were used, flow rate 1 mL min−1 and monitored at 350 nm. Linearity proved satisfactory between 0.025 and 2.5 μg mL−1 of serum. This assay for doxycycline showed good precision (coefficient of variation <6%) and allowed quantitation of serum levels as low as 25 ng mL−1 using 100 μL samples. More... »

PAGES

524-526

Journal

TITLE

Chromatographia

ISSUE

9-12

VOLUME

35

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf02267911

DOI

http://dx.doi.org/10.1007/bf02267911

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1051538324


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