Bioanalysis of fluorouracil applying liquid chromatography and valve switching View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1988-09

AUTHORS

U. R. Tjaden, H. Lingeman, H. J. E. M. Reeuwijk, E. A. de Bruijn, H. J. Keizer, J. van der Greef

ABSTRACT

Fluorouracil has been analyzed with a reversed-phase ion-pair liquid chromatographic system applying PRP-1 as the stationary phase. A valve switching technique was applied for the separation of the analyte and some other chemotherapeutic agents. The described procedure gives a rapid screening for the analyte in urine and plasma samples without interferences from late eluting solutes. Biological samples are pretreated by means of a liquid-liquid extraction resulting in a recovery of about 52% for plasma and urine with minimum detectable amounts of about 5ng/ml. The sensitivity and the selectivity of the procedure allows the monitoring of fluorouracil in body fluids and subsequent pharmaco-kinetic studies of the fluoropyrimidine. More... »

PAGES

806-810

Journal

TITLE

Chromatographia

ISSUE

9

VOLUME

25

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf02262089

DOI

http://dx.doi.org/10.1007/bf02262089

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1030105740


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