Lentiviral vectors View Full Text


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Article Info

DATE

2004-07

AUTHORS

Andrew M. L. Lever, Padraig M. Strappe, Jing Zhao

ABSTRACT

Vectors based on lentiviruses have reached a state of development such that clinical studies using these agents as gene delivery vehicles have now begun. They have particular advantages for certain in vitro and in vivo applications especially the unique capability of integrating genetic material into the genome of non-dividing cells. Their rapid progress into clinical use reflects in part the huge body of knowledge which has accumulated about HIV in the last 20 years. Despite this, many aspects of viral assembly on which the success of these vectors depends are rather poorly understood. Sufficient is known however to be able to produce a safe and reproducible high titre vector preparation for effective transduction of growth-arrested tissues such as neural tissue, muscle and liver. More... »

PAGES

439-449

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/bf02256092

    DOI

    http://dx.doi.org/10.1007/bf02256092

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1037893626

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/15153778


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    RDF/XML is a standard XML format for linked data.

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