Intraperitoneal hyperthermic treatment for peritoneal dissemination of colorectal cancers View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1992-10

AUTHORS

Akio Yamaguchi, Yuuji Tsukioka, Sachio Fushida, Yoshiyuki Kurosaka, Masahiro Kanno, Yutaka Yonemura, Kouichi Miwa, Itsuo Miyazaki

ABSTRACT

Continuous hyperthermic peritoneal perfusion (CHPP) combined with administration of anticancer drugs was performed in eight colorectal cancer patients with peritoneal dissemination. An overall response rate of 50 percent was achieved in the eight patients. Two of three complete responders are long, recurrence-free survivors for 15 and 30 months. The two-year survival has been achieved in 18.8 percent of the patients receiving CHPP, and this rate is significantly higher than the rates in P2 and P3 patients who did not receive CHPP. The complications of CHPP with administration of anticancer drugs were mild bone marrow suppression in two (25 percent) of the eight patients and also a mild grade of renal dysfunction in one (12.5 percent), though not lethal. The results suggest that the combination of CHPP with the administration of anticancer drugs is a safe and effective therapy for peritoneal dissemination of colorectal cancers. More... »

PAGES

964-968

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf02253499

DOI

http://dx.doi.org/10.1007/bf02253499

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1047347911

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/1395984


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