Inhibition of REM sleep by ipsapirone, A 5HT1A agonist, in normal volunteers View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1994-12

AUTHORS

J. Christian Gillin, Wojciech Jernajczyk, Dirceu de C. Valladares-Neto, Shahrokh Golshan, Michael Lardon, Stephen M. Stahl

ABSTRACT

In order to test the hypothesis that serotonergic mechanisms inhibit REM sleep via a 5HT1A receptor, we administered placebo and ipsapirone (10 and 20 mg by mouth 15 min before bedtime) to ten normal volunteers in a double blind fashion. Ipsapirone is a relatively selective 5HT1A receptor agonist. As predicted, ipsapirone prolonged REM latency and Mean Latency to Eye Movements (M-LEM), a measure of time between onset of REM sleep and the first eye movement of the REM period, and REM% at both doses compared with placebo. It also reduced sleep efficiency and total REM sleep time at the highest dose. These results support the hypothesis that systemic stimulation of 5HT1A receptors prolong REM latency and inhibit REM sleep. More... »

PAGES

433-436

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf02247474

DOI

http://dx.doi.org/10.1007/bf02247474

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1035223090

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/7701045


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