Reduced haloperidol plasma concentration and clinical response in acute exacerbations of schizophrenia View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1990-12

AUTHORS

Michael W. Kelly, Paul J. Perry, William H. Coryell, D. Del Miller, Stephan V. Arndt

ABSTRACT

Twenty-nine hospitalized patients suffering acute exacerbations of schizophrenia were treated for 2 weeks with fixed daily oral doses of haloperidol prospectively calculated to achieve a haloperidol plasma concentration of either 8-18 ng/ml or 25-35 ng/ml. Reduced haloperidol as well as haloperidol concentrations were assayed to determine if the former enhanced the predictability of response. Wee 2 haloperidol plasma concentrations were negatively correlated to clinical response as measured by the percentage change in the BPRS score from baseline (r = -0.43, P less than 0.05). In contrast, week 2 plasma concentrations of reduced haloperidol, total haloperidol (haloperidol + reduced haloperidol), and reduced haloperidol/haloperidol ratio did not correlate with the change in the BPRS score. Chi-square analysis concluded that patients with ratios greater than one were no less likely to be treatment responders (less than 25% improvement in BPRS from baseline and week 2 BPRS less than 55) than those with ratios less than one. Although these data lend additional support to reports of a curvilinear relationship between haloperidol plasma concentration and clinical response, they also suggest that reduced haloperidol plasma concentrations are of no value in predicting treatment response. More... »

PAGES

514-520

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf02247134

DOI

http://dx.doi.org/10.1007/bf02247134

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1047742637

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/2096408


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