Bretazenil modulates sleep EEG and nocturnal hormone secretion in normal men View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1995-11

AUTHORS

J. Guldner, L. Trachsel, C. Kratschmayr, B. Rothe, F. Holsboer, A. Steiger

ABSTRACT

Preclinical data suggest that the imidazodiazepinone derivative bretazenil (Ro 16-6028) has anxiolytic and anticonvulsant properties with only weak sedative effects. We examined the influence of oral administration of 1 mg bretazenil on the sleep EEG and the concomitant nocturnal secretion of cortisol, growth hormone and prolactin in ten healthy young men. After bretazenil we found a significant increase in stage 2 sleep and a significant reduction in stage 3 sleep. REM latency was prolonged. Spectral analysis of sleep-EEG power revealed a decrease in delta and in theta power and an increase in sigma power. We found no significant influence on sleep onset latency or on intermittent wakefulness. Bretazenil prompted a significant decrease in cortisol secretion and a significant increase in prolactin release. It had no major influence on growth hormone secretion. More... »

PAGES

115-121

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf02246085

DOI

http://dx.doi.org/10.1007/bf02246085

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1020574547

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/8848526


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