Rewarding and aversive properties of IP and SC cocaine: assessment by place and taste conditioning View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1993-09

AUTHORS

Lori A. Mayer, Linda A. Parker

ABSTRACT

Three experiments were conducted to compare the effectiveness of intraperitoneally (IP) administered or subcutaneously (SC) administered cocaine to produce place and/or taste conditioning after four conditioning trials. In each experiment, IP (5-20 mg/kg) cocaine produced a place preference, but SC (0.5-20 mg/kg) cocaine at concentrations that prevented necrosis, did not produce a place preference. The failure of SC cocaine to produce a place preference was not a function of conditioning trial duration. On the other hand, SC cocaine (20 mg/kg) produced conditioned taste avoidance, but IP cocaine (20 mg/kg) did not produce conditioned taste avoidance. The results suggest that IP cocaine, but not SC cocaine, is rewarding. More... »

PAGES

189-194

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf02244909

DOI

http://dx.doi.org/10.1007/bf02244909

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1028230403

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/7871018


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