Benzodiazepine-induced sedation and cortisol suppression View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1992-04

AUTHORS

P. Christensen, A. Lolk, L. F. Gram, P. Kragh-Sørensen

ABSTRACT

The sedative and cortisol suppressing properties of oxazepam (45 and 60 mg) and nitrazepam (10 and 15 mg) were examined in eight healthy male subjects. The most clear differences between oxazepam and nitrazepam were those seen with respect to the time course and until maximal effect (Tmax) of the different measurements. Nitrazepam showed maximal sedation after 1 h, maximal benzodiazepine level (RRA), and reaction time prolongation after 2 h, and maximal cortisol suppression after 3 h. Oxazepam showed maximal sedation after 2 h, maximal benzodiazepine levels, reaction time prolongation and cortisol suppression after 3 h. After administration of oxazepam (both doses) a transient return to baseline levels of cortisol was demonstrated. Whereas the degree of sedation correlated significantly within drug groups with the concurrent benzodiazepine levels, the Tmax of sedation was recorded 1 h earlier than the peak blood concentration (RRA) for both nitrazepam and oxazepam. The time course for cortisol suppression for the two compounds differed clearly from the other measurements and was not related to the peak blood concentration. More... »

PAGES

511-516

References to SciGraph publications

  • 1984. Pharmacokinetic and Clinical Studies with a Benzodiazepine Radioreceptor Assay in SLEEP, BENZODIAZEPINES AND PERFORMANCE
  • 1985. Clinical Pharmacokinetics of the Benzodiazepines in THE BENZODIAZEPINES: CURRENT STANDARDS FOR MEDICAL PRACTICE
  • 1985. Acute and Chronic Toxicity of Benzodiazepines in THE BENZODIAZEPINES: CURRENT STANDARDS FOR MEDICAL PRACTICE
  • 1985. Principles of Therapeutic Applications of Benzodiazepines in THE BENZODIAZEPINES: CURRENT STANDARDS FOR MEDICAL PRACTICE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/bf02244823

    DOI

    http://dx.doi.org/10.1007/bf02244823

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1051208159

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/1349754


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