Role of D-1 and D-2 receptor stimulation in sensitization to amphetamine-induced circling behavior and in expression and extinction of the ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1990-08

AUTHORS

Kelly L. Drew, Stanley D. Glick

ABSTRACT

Circling behavior was measured in female rats treated with amphetamine (1.25 mg/kgd-amphetamine sulfate, IP) on 3 consecutive days. On days 4 and 5 saline was substituted for amphetamine. While the amphetamine-induced response was attenuated by both a D-1 (SCH 23390) and a D-2 (metoclopramide) antagonist, sensitization to amphetamine was attenuated by the D-1 antagonist only. In addition, expression of a placebo-like response observed on day 4 (characterized previously as a Pavlovian conditioned response) was attenuated by both the D-1 and D-2 antagonists without disrupting extinction of the response. More... »

PAGES

465-471

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf02244223

DOI

http://dx.doi.org/10.1007/bf02244223

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1016319564

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/2201989


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