Intralesional administration of I-131 labelled monoclonal antibodies in the treatment of malignant gliomas View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1995-09

AUTHORS

A. Arista, C. Sturiale, P. Riva, V. Tison, M. Frattarelli, G. Moscatelli, G. Franceschi, A. Spinelli

ABSTRACT

The authors report their preliminary experience with the use of radiolabelled monoclonal antibodies (MAb) as an adjuvant treatment for 33 malignant gliomas. MAbs employed in this study are raised against Tenascin (TN) which is an antigen of the extracellular matrix of the tumour. It has also been found in neoplastic cells but never in normal brain tissue. This therapy is aimed to give a local high dose radiation (boost) while sparing healthy brain structures.This treatment has always been well tolerated and no adverse reactions at the level of CNS or major extraneural organs has been observed. Significant improvement of median survival has been obtained but this result should be cautiously evaluate since the study is non-randomized. Comparison with other current adjuvant technique is briefly discussed. More... »

PAGES

159-162

References to SciGraph publications

  • 1975-08. Continuous cultures of fused cells secreting antibody of predefined specificity in NATURE
  • 1992. Radiosurgery in ADVANCES AND TECHNICAL STANDARDS IN NEUROSURGERY
  • 1986-10. Radioimmunolocalisation of human brain tumours: Biodistribution of radiolabelled monoclonal antibody UJ13A in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/bf02187762

    DOI

    http://dx.doi.org/10.1007/bf02187762

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1042591080

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/8748808


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