Über einige pharmakologische Untersuchungen synthetischer Alkoxy-tropinderivate View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1954-03

AUTHORS

E. Rothlin, M. Taeschler, H. Konzett, A. Cerletti

ABSTRACT

Some pharmacological properties of new synthetic alkoxy-tropine derivatives are reported. The tertiary compounds were relatively potent local anaesthetics with a low anti-cholinergic action. Acetylcholine inhibition, as well as the spasmolytic activityin vivo of the benzilic acid esters were markedly increased by quaternisation while their toxicity decreased. 6-Methoxytropine benzilic acid ester brom-methylate was the most active compound of this series. A pronounced inhibitory activity on neurogenically induced intestinal constriction was found in low doses, whereas larger doses exerted a ganglionic blocking effect. More... »

PAGES

142-145

References to SciGraph publications

  • 1951-12. Pharmakologie des Buscopan in NAUNYN-SCHMIEDEBERGS ARCHIV FÜR EXPERIMENTELLE PATHOLOGIE UND PHARMAKOLOGIE
  • 1917-06. Ueber die Wirkung der Tropeine und ihrer quaternären Ammoniumbasen in ZEITSCHRIFT FÜR DIE EXPERIMENTELLE PATHOLOGIE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/bf02158523

    DOI

    http://dx.doi.org/10.1007/bf02158523

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1003502020

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/13161897


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