JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Astrocytes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Bucladesine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Division", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cerebellar Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glial Fibrillary Acidic Protein", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Infant", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Medulloblastoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tretinoin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Cells, Cultured", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Neuro-Oncology, The University of Texas and M.D. Anderson Cancer Center, 1515 Holcombe Blvd, 77030, Houston, TX, USA", 
          "id": "http://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Neuro-Oncology, The University of Texas and M.D. Anderson Cancer Center, 1515 Holcombe Blvd, 77030, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Maria", 
        "givenName": "Bernard L.", 
        "id": "sg:person.01224662515.58", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01224662515.58"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Neuro-Oncology, The University of Texas and M.D. Anderson Cancer Center, 1515 Holcombe Blvd, 77030, Houston, TX, USA", 
          "id": "http://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Neuro-Oncology, The University of Texas and M.D. Anderson Cancer Center, 1515 Holcombe Blvd, 77030, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Steck", 
        "givenName": "Peter A.", 
        "id": "sg:person.01045217417.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01045217417.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Neuro-Oncology, The University of Texas and M.D. Anderson Cancer Center, 1515 Holcombe Blvd, 77030, Houston, TX, USA", 
          "id": "http://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Neuro-Oncology, The University of Texas and M.D. Anderson Cancer Center, 1515 Holcombe Blvd, 77030, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yung", 
        "givenName": "W. K. Alfred", 
        "id": "sg:person.016341673457.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016341673457.32"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Experimental Pathology, The University of Texas and M.D. Anderson Cancer Center, 1515 Holcombe Blvd, 77030, Houston, TX, USA", 
          "id": "http://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Experimental Pathology, The University of Texas and M.D. Anderson Cancer Center, 1515 Holcombe Blvd, 77030, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Milici", 
        "givenName": "Antonio", 
        "id": "sg:person.0626764305.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0626764305.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Neuropathology, The University of Texas and M.D. Anderson Cancer Center, 1515 Holcombe Blvd, 77030, Houston, TX, USA", 
          "id": "http://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Neuropathology, The University of Texas and M.D. Anderson Cancer Center, 1515 Holcombe Blvd, 77030, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bruner", 
        "givenName": "Janet M.", 
        "id": "sg:person.013375073077.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013375073077.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Cell Biology, The University of Texas and M.D. Anderson Cancer Center, 1515 Holcombe Blvd, 77030, Houston, TX, USA", 
          "id": "http://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Cell Biology, The University of Texas and M.D. Anderson Cancer Center, 1515 Holcombe Blvd, 77030, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pathak", 
        "givenName": "Sen", 
        "id": "sg:person.01242663427.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01242663427.43"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Experimental Pathology, The University of Texas and M.D. Anderson Cancer Center, 1515 Holcombe Blvd, 77030, Houston, TX, USA", 
          "id": "http://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Experimental Pathology, The University of Texas and M.D. Anderson Cancer Center, 1515 Holcombe Blvd, 77030, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Becker", 
        "givenName": "Frederick F.", 
        "id": "sg:person.016234004223.65", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016234004223.65"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/bf00691533", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012708585", 
          "https://doi.org/10.1007/bf00691533"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01148315", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023901619", 
          "https://doi.org/10.1007/bf01148315"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00688264", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009026815", 
          "https://doi.org/10.1007/bf00688264"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00321168", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009636574", 
          "https://doi.org/10.1007/bf00321168"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00583584", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002535092", 
          "https://doi.org/10.1007/bf00583584"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1989-12", 
    "datePublishedReg": "1989-12-01", 
    "description": "Medulloblastomas are cerebellar tumors which are primarily composed of sheets of uniform, small malignant cells and may have astrocytic, neuronal or no features typical of these cell types. The assessment of astrocytic differentiation in medulloblastoma rests largely on the detection in malignant cells of glial fibrillary acidic protein (GFAP), a marker present in the later stages of normal astrocyte differentiation. It is still not known whether cells that do not contain GFAP in medulloblastomas with astrocytic differentiation correspond to highly proliferative astrocyte progenitors in maturation arrest at earlier stages of differentiation. The purpose of the current study was to examine whether cells in short term culture derived from a medulloblastoma tumor specimen with astrocytic differentiation were of the astrocytic lineage and if so, whether they represented proliferative astrocyte progenitors which would morphologically and antigenically mature in response to differentiating agents. A portion of tumor specimen from a 10-month-old child with recurrent posterior fossa medulloblastoma (RB2) that contained GFAP focally in tumor cells was grown in monolayer culture. We examined cellular structure and appearance of western immunoblotting and immunohistochemical studies for GFAP and neuron-specific enolase (NSE) in RB2 cells before and after treatment with retinoic acid (RA) and dibutyryl cyclic AMP (dBcAMP). RB2 in culture consisted of small polygonal cells (93%), large flat cells (3%), and polygonal cells with cytoplasmic processes (4%). In untreated RB2, 30% of cells expressed GFAP and staining for NSE was negative. RA treatment produced flattened cells and decreased GFAP. DBcAMP reversibly induced fine cytoplasmic processes containing GFAP in 85% of cells within 96h. Neither agent induced NSE. The results suggest that cultured cells which are derived from a medulloblastoma with astrocytic differentiation do not spontaneously differentiate but that treatment with dBcAMP suppresses proliferation, enhances cytoplasmic process formation and increases cytoplasmic GFAP. Cells in culture and in medulloblastoma tumor specimens which do not contain GFAP may represent astrocyte progenitors in maturation arrest.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/bf02147090", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1094205", 
        "issn": [
          "0167-594X", 
          "1573-7373"
        ], 
        "name": "Journal of Neuro-Oncology", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "4", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "7"
      }
    ], 
    "keywords": [
      "glial fibrillary acidic protein", 
      "neuron-specific enolase", 
      "astrocytic differentiation", 
      "astrocyte progenitors", 
      "maturation arrest", 
      "tumor specimen", 
      "cytoplasmic glial fibrillary acidic protein", 
      "malignant cells", 
      "retinoic acid", 
      "polygonal cells", 
      "fibrillary acidic protein", 
      "posterior fossa medulloblastoma", 
      "cytoplasmic processes", 
      "small malignant cells", 
      "short-term culture", 
      "dibutyryl cyclic AMP", 
      "surgical specimen", 
      "sheets of uniform", 
      "immunohistochemical study", 
      "tumor specimens", 
      "cerebellar tumors", 
      "astrocytic lineage", 
      "RA treatment", 
      "fine cytoplasmic processes", 
      "suppress proliferation", 
      "small polygonal cells", 
      "medulloblastoma", 
      "acidic protein", 
      "tumor cells", 
      "large flat cells", 
      "Western immunoblotting", 
      "astrocyte differentiation", 
      "cyclic AMP", 
      "treatment", 
      "term culture", 
      "cell types", 
      "cells", 
      "marker present", 
      "monolayer cultures", 
      "cultured cells", 
      "arrest", 
      "current study", 
      "cytoplasmic process formation", 
      "differentiation", 
      "process formation", 
      "progenitors", 
      "early stages", 
      "flat cells", 
      "agents", 
      "tumors", 
      "later stages", 
      "enolase", 
      "dbcAMP", 
      "children", 
      "immunoblotting", 
      "study", 
      "AMP", 
      "culture", 
      "proliferation", 
      "Rb2", 
      "specimen", 
      "stage", 
      "assessment", 
      "response", 
      "rest", 
      "modulation", 
      "protein", 
      "specimens", 
      "appearance", 
      "acid", 
      "purpose", 
      "portion", 
      "detection", 
      "lineages", 
      "types", 
      "present", 
      "features", 
      "results", 
      "cellular structure", 
      "formation", 
      "process", 
      "sheets", 
      "structure", 
      "uniform"
    ], 
    "name": "The modulation of astrocytic differentiation in cells derived from a medulloblastoma surgical specimen", 
    "pagination": "329-338", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1046827803"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/bf02147090"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "2555453"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/bf02147090", 
      "https://app.dimensions.ai/details/publication/pub.1046827803"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-05-10T09:42", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220509/entities/gbq_results/article/article_204.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/bf02147090"
  }
]

Download the RDF metadata as:  json-ld nt turtle xml License info

This table displays all metadata directly associated to this object as RDF triples.

262 TRIPLES      22 PREDICATES      128 URIs      114 LITERALS      18 BLANK NODES