Influence of ring substituents on the antitumor effect of dichloro(1,2-diphenylethylenediamine)platinum(II) complexes View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1988-08

AUTHORS

Margaretha Jennerwein, Beate Wappes, Ronald Gust, Helmut Schönenberge, Jürgen Engel, Siegfried Seeber, Reinhardt Osieka

ABSTRACT

Diastereomeric para-substituted dichloro(1,2-diphenylethylenediamine)platinum(II) complexes were synthesized and tested for their antitumor activity on the human MDA-MB 231 breast cancer cell line and the P 388 leukemia of the mouse. An interaction with the DNA was demonstrated by UV difference spectroscopy. The D,L configurated, 4-fluoro-substituted complex was the most active.

PAGES

347-358

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf02128177

DOI

http://dx.doi.org/10.1007/bf02128177

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1018699026

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/3410875


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