Nonrandomness of point mutation as reflected in nucleotide substitutions in pseudogenes and its evolutionary implications View Full Text


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Article Info

DATE

1984-11

AUTHORS

Wen-Hsiung Li, Chung-I Wu, Chi-Cheng Luo

ABSTRACT

We have obtained a revised estimate of the pattern of point mutation by considering more pseudogene sequences. Compared with our previous estimate, it agrees better with expectations based on the double-strand structure of DNA. The revised pattern, like the previous one, indicates that mutation occurs nonrandomly among the four nucleotides. In particular, the proportion of transitional mutations (59%) is almost twice as high as the value (33%) expected under random mutation. The same high proportion of transitions is observed in synonymous substitutions in genes. The proportion of transitional changes observed among electrophoretic variants of human hemoglobin is about the same as that predicted by the revised pattern of mutation. We also show that nonrandom mutation increases, by about 15%, the proportion of synonymous mutations due to single-nucleotide changes in the codon table, and increases, from 10% to 50%, the rate of synonymous mutation in the seven genes studied. However, nonrandom mutation reduces (by about 10%) the proportion of polar changes among nonsynonymous mutations in a gene. As far as single-nucleotide changes (in the codon table) are concerned, nonrandom mutation only slightly favors relatively conservative amino acid interchanges, and has virtually no effect on the proportions of radical changes and nonsense mutations. More... »

PAGES

58-71

References to SciGraph publications

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  • 1965-01. Sind die Mutationsraten für die X-chromosomal recessiven Hämophilieformen in Keimzellen von Frauen niedriger als in Keimzellen von Männern? in HUMANGENETIK
  • 1977-05. Preponderance of synonymous changes as evidence for the neutral theory of molecular evolution in NATURE
  • 1978-08. Molecular basis of base substitution hotspots in Escherichia coli in NATURE
  • 1977-06. Higher frequencies of transitions among point mutations in JOURNAL OF MOLECULAR EVOLUTION
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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/bf02100628

    DOI

    http://dx.doi.org/10.1007/bf02100628

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1027463430

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/6442359


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