Der Einflu\ biogener Amine auf die Atmung und den kleinen Kreislauf View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1970-03

AUTHORS

E. Kammler, W. Weller, M. S. Islam, R. Sell, W. T. Ulmer

ABSTRACT

Die an 30 Hunden durchgeführten Versuche zeigen, daß Acetylcholin-Infusionen in den rechten Vorhof und den Truncus bicaroticus mit einer Dosis, bei welcher der Blutdruck im großen Kreislauf nur wenig beeinflußt wird, keine wesentliche Ventilationsstörung und Wirkung auf den kleinen Kreislauf hervorzurufen vermag. Am Beginn der Injektion kommt es lediglich zu kurzzeitigen Atmungsreaktionen. Bei Acetylcholininhalation kommt es dagegen zu einer beim Menschen häufig zu beobachtenden mehr inhomogenen, peripheren, obstruktiven Ventilationsstörung mit im Verhältnis zur Steigerung der Strömungswiderstände schweren Störung des Gasaustausches mit Pulmonalisdruckerhöhung und Atemfrequenzsteigerung. Die Blutdruckverhältnisse können hierbei normal sein. Tierexperimentell läßt sich mit Acetylcholin ein klinisches Bild erzeugen, welches weitgehend der schweren obstruktiven Atemwegserkrankung des Menschen gleicht. Die Regulation der Atemfrequenz hängt weitgehend von der Lokalisation der Atemwegsobstruktion ab. Periphere Obstruktion verursacht besondere Steigerung der Atemfrequenz mit erheblicher Zunahme des funktionellen Tortraumes. Unter der Hypoxie bei alveolärer Hypoventilation steigt der Druck in der Arteria pulmonalis an. Direkte Wirkungen von Acetylcholin auf den Lungenkreislauf konnten nicht nachgewiesen werden. Die acetylcholinbedingte „biochemische Atemwegsobstruktion“ ist relativ rasch reversibel. Sie läßt sich auch durch Überdruckbeatmung beseitigen. Eine Tachyphylaxie der Acetylcholinwirkung am Bronchialbaum konnte in Versuchen über 5 Std nicht nachgewiesen werden. Es wird angenommen, daß bei der Atemwegsobstruktion des Menschen Acetylcholin eine entscheidende Rolle spielt. More... »

PAGES

67-82

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf02095941

DOI

http://dx.doi.org/10.1007/bf02095941

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1025801946

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/5515496


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