Trypsin(ogen) content of pancreatic calculi in chronic calcified pancreatitis in man View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1994-06

AUTHORS

Tetsuo Hayakawa, Takaharu Kondo, Tokimune Shibata, Motoji Kitagawa, Yasuyuki Nakae, Shinobu Hayakawa

ABSTRACT

Protein analysis of intraductal precipitates and calculi is important to elucidate the mechanism of stone formation in chronic pancreatitis. We revealed human cationic trypsin immunoreactivity in protein extracts of pancreatic stones from 11 of 13 patients with chronic calcified pancreatitis, ranging from 0 to 42.3 ng/µg protein. On gel filtration the immunoreactivity eluted as one peak, which is identical to that of human cationic trypsinogen. On immunostaining of pancreatic stone, using an immunogold technic and scanning electron microscopy, the immunoreactivity was observed more densely in the amorphous portion of the center of the stones than in the concentric laminar layer of the periphery. Only negligible activity was detected for elastase 1 or amylase in the stone extracts. These results suggest that the presence of trypsinogen in pancreatic stone is not due to coprecipitation or adsorption of pancreatic enzymes but that trypsinogen is more likely involved in an initial step of intraductal precipitate formation than in a subsequent step of stone formation. However, the absence of trypsinogen in the stones from two of the 13 patients also suggests that trypsinogen is not the sole protein initiating precipitate formation. More... »

PAGES

1345-1350

References to SciGraph publications

  • 1992-04. Peritoneal absorption of pancreatic enzymes in dogs in JOURNAL OF GASTROENTEROLOGY
  • 1991-11. Differences of pancreatic stone morphology and content in patients with pancreatic lithiasis in DIGESTIVE DISEASES AND SCIENCES
  • 1986-09. Etiopathogenesis and definition of chronic pancreatitis in DIGESTIVE DISEASES AND SCIENCES
  • 1974-07. Free proteolytic enzymes in pancreatic juice of patients with acute pancreatitis in DIGESTIVE DISEASES AND SCIENCES
  • 1992-02. Molecular form of pancreatic elastase 1 in human plasma in JOURNAL OF GASTROINTESTINAL CANCER
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/bf02093803

    DOI

    http://dx.doi.org/10.1007/bf02093803

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1017948055

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/8200269


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