Tissue-specific alterations of binding sites for peripheral-type benzodiazepine receptor ligand [3H]PK11195 in rats following portacaval anastomosis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1994-05

AUTHORS

V. L. Raghavendra Rao, Robert Audet, Guy Therrien, Roger F. Butterworth

ABSTRACT

Kinetics of binding of [3H]PK11195, an antagonist ligand with high selectivity for the peripheral-type (mitochondrial) benzodiazepine receptor (PTBR), was studied in homogenates of cerebral cortex, kidney, heart, and testis of portacaval shunted rats and sham-operated controls. Portacaval anastomosis resulted in a significant two- to threefold increase in the number of [3H]PK11195 binding sites in cerebral cortex and kidney. A reduction in the number of [3H]PK11195 binding sites was observed in testis preparations, while the number of binding sites in the heart remained unaltered. These differences in the response of PTBRs to portacaval anastomosis, in different organs suggest that the physiological function of these receptors and the factors regulating them are modulated by distinct mechanisms. The finding of increased densities of [3H]PK11195 binding sites in brain and kidney following portacaval anastomosis parallels the cellular hypertrophy in these tissues and, together with previous observations of similar increases of these binding sites in brain and kidney in congenital hyperammonemia, suggest a pathophysiologic role for ammonia in these changes. In contrast, the significant loss of [3H]PK11195 binding sites in testicular preparations following portacaval anastomosis together with the known effects of steroid hormones on these sites suggests a role for PTBRs in the pathogenesis of testicular atrophy in chronic liver disease. More... »

PAGES

1055-1063

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf02087558

DOI

http://dx.doi.org/10.1007/bf02087558

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1046479097

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/8174418


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Binding Sites", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cerebral Cortex", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Isoquinolines", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Kidney", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Myocardium", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Portacaval Shunt, Surgical", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats, Sprague-Dawley", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, GABA-A", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Testis", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Montreal", 
          "id": "https://www.grid.ac/institutes/grid.14848.31", 
          "name": [
            "From the Neuroscience Research Unit, H\u00f4pital Saint-Luc, (University of Montreal), H2X 3J4, Montreal, Quebec, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Raghavendra Rao", 
        "givenName": "V. L.", 
        "id": "sg:person.0721644076.95", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721644076.95"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Montreal", 
          "id": "https://www.grid.ac/institutes/grid.14848.31", 
          "name": [
            "From the Neuroscience Research Unit, H\u00f4pital Saint-Luc, (University of Montreal), H2X 3J4, Montreal, Quebec, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Audet", 
        "givenName": "Robert", 
        "id": "sg:person.0767757276.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0767757276.25"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Montreal", 
          "id": "https://www.grid.ac/institutes/grid.14848.31", 
          "name": [
            "From the Neuroscience Research Unit, H\u00f4pital Saint-Luc, (University of Montreal), H2X 3J4, Montreal, Quebec, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Therrien", 
        "givenName": "Guy", 
        "id": "sg:person.01165473546.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01165473546.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Montreal", 
          "id": "https://www.grid.ac/institutes/grid.14848.31", 
          "name": [
            "From the Neuroscience Research Unit, H\u00f4pital Saint-Luc, (University of Montreal), H2X 3J4, Montreal, Quebec, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Butterworth", 
        "givenName": "Roger F.", 
        "id": "sg:person.0765176464.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0765176464.29"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/0014-2999(81)90092-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001543941"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0014-2999(81)90092-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001543941"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00688851", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002522454", 
          "https://doi.org/10.1007/bf00688851"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1471-4159.1992.tb10030.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003801277"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2362.1976.tb00540.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004064798"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0014-2999(86)90218-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004925465"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0014-2999(86)90218-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004925465"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00999904", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009902663", 
          "https://doi.org/10.1007/bf00999904"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0024-3205(81)90744-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011271217"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0024-3205(81)90744-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011271217"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0196-9781(91)90177-q", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011355384"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0304-3940(91)90408-l", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012476578"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0304-3940(91)90408-l", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012476578"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0091-3057(86)90504-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021343050"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0091-3057(86)90504-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021343050"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hep.1840110524", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024265416"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ana.410260109", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024693499"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.pa.22.040182.001333", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025149321"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00005072-197407000-00008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032165880"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0165-6147(86)90438-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032285632"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.84.8.2256", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034744495"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0014-2999(83)90658-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035624099"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0014-2999(83)90658-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035624099"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0014-2999(85)90026-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037312403"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0014-2999(85)90026-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037312403"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-8993(92)91222-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037675819"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-8993(92)91222-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037675819"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.81.3.753", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045290299"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1203/00006450-199312000-00016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046106234", 
          "https://doi.org/10.1203/00006450-199312000-00016"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1471-4159.1990.tb05790.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049124628"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/endo-116-2-567", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064258588"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076540342", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076664765", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076750128", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078391987", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078392916", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079421008", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079580406", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081547094", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081867515", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081993179", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1994-05", 
    "datePublishedReg": "1994-05-01", 
    "description": "Kinetics of binding of [3H]PK11195, an antagonist ligand with high selectivity for the peripheral-type (mitochondrial) benzodiazepine receptor (PTBR), was studied in homogenates of cerebral cortex, kidney, heart, and testis of portacaval shunted rats and sham-operated controls. Portacaval anastomosis resulted in a significant two- to threefold increase in the number of [3H]PK11195 binding sites in cerebral cortex and kidney. A reduction in the number of [3H]PK11195 binding sites was observed in testis preparations, while the number of binding sites in the heart remained unaltered. These differences in the response of PTBRs to portacaval anastomosis, in different organs suggest that the physiological function of these receptors and the factors regulating them are modulated by distinct mechanisms. The finding of increased densities of [3H]PK11195 binding sites in brain and kidney following portacaval anastomosis parallels the cellular hypertrophy in these tissues and, together with previous observations of similar increases of these binding sites in brain and kidney in congenital hyperammonemia, suggest a pathophysiologic role for ammonia in these changes. In contrast, the significant loss of [3H]PK11195 binding sites in testicular preparations following portacaval anastomosis together with the known effects of steroid hormones on these sites suggests a role for PTBRs in the pathogenesis of testicular atrophy in chronic liver disease.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/bf02087558", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1018525", 
        "issn": [
          "0163-2116", 
          "1573-2568"
        ], 
        "name": "Digestive Diseases and Sciences", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "39"
      }
    ], 
    "name": "Tissue-specific alterations of binding sites for peripheral-type benzodiazepine receptor ligand [3H]PK11195 in rats following portacaval anastomosis", 
    "pagination": "1055-1063", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "dd6868e5e9950fda300495ca1f7437a928f6bd827a0c08f3935a64053a44517b"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "8174418"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "7902782"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/bf02087558"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1046479097"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/bf02087558", 
      "https://app.dimensions.ai/details/publication/pub.1046479097"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T11:54", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000359_0000000359/records_29203_00000002.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007/BF02087558"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/bf02087558'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/bf02087558'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/bf02087558'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/bf02087558'


 

This table displays all metadata directly associated to this object as RDF triples.

230 TRIPLES      21 PREDICATES      74 URIs      33 LITERALS      21 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/bf02087558 schema:about N09c4ee63541b478bb9b7795f5dd104bf
2 N12ffc27689b24449b44813b412890600
3 N472ef82cc09e40a9b0b9c1aafaeee326
4 N4bee59b8942947ba804ab1171d1355f0
5 N4d2be91b605e4e33a8d248463932764c
6 N59359ccc3c0d4e479669dffc1329bfb2
7 N5ddee183396a487cabe0b14537248a9e
8 N5f42fcc7497e4c2dab343299c0882b1e
9 Na19d20dc65d64bcfae92640814e0765e
10 Na6a92f07640c4709897594aa9f3fc1cb
11 Nb3242ab5c65c41299c0d0316f5769062
12 Ne450aaadb4e448a592a3191be3ee6c8e
13 anzsrc-for:11
14 anzsrc-for:1103
15 schema:author N4a03144655b84093b8ccbc3c70dac431
16 schema:citation sg:pub.10.1007/bf00688851
17 sg:pub.10.1007/bf00999904
18 sg:pub.10.1203/00006450-199312000-00016
19 https://app.dimensions.ai/details/publication/pub.1076540342
20 https://app.dimensions.ai/details/publication/pub.1076664765
21 https://app.dimensions.ai/details/publication/pub.1076750128
22 https://app.dimensions.ai/details/publication/pub.1078391987
23 https://app.dimensions.ai/details/publication/pub.1078392916
24 https://app.dimensions.ai/details/publication/pub.1079421008
25 https://app.dimensions.ai/details/publication/pub.1079580406
26 https://app.dimensions.ai/details/publication/pub.1081547094
27 https://app.dimensions.ai/details/publication/pub.1081867515
28 https://app.dimensions.ai/details/publication/pub.1081993179
29 https://doi.org/10.1002/ana.410260109
30 https://doi.org/10.1002/hep.1840110524
31 https://doi.org/10.1016/0006-8993(92)91222-z
32 https://doi.org/10.1016/0014-2999(81)90092-3
33 https://doi.org/10.1016/0014-2999(83)90658-1
34 https://doi.org/10.1016/0014-2999(85)90026-3
35 https://doi.org/10.1016/0014-2999(86)90218-9
36 https://doi.org/10.1016/0024-3205(81)90744-x
37 https://doi.org/10.1016/0091-3057(86)90504-6
38 https://doi.org/10.1016/0165-6147(86)90438-4
39 https://doi.org/10.1016/0196-9781(91)90177-q
40 https://doi.org/10.1016/0304-3940(91)90408-l
41 https://doi.org/10.1073/pnas.81.3.753
42 https://doi.org/10.1073/pnas.84.8.2256
43 https://doi.org/10.1097/00005072-197407000-00008
44 https://doi.org/10.1111/j.1365-2362.1976.tb00540.x
45 https://doi.org/10.1111/j.1471-4159.1990.tb05790.x
46 https://doi.org/10.1111/j.1471-4159.1992.tb10030.x
47 https://doi.org/10.1146/annurev.pa.22.040182.001333
48 https://doi.org/10.1210/endo-116-2-567
49 schema:datePublished 1994-05
50 schema:datePublishedReg 1994-05-01
51 schema:description Kinetics of binding of [3H]PK11195, an antagonist ligand with high selectivity for the peripheral-type (mitochondrial) benzodiazepine receptor (PTBR), was studied in homogenates of cerebral cortex, kidney, heart, and testis of portacaval shunted rats and sham-operated controls. Portacaval anastomosis resulted in a significant two- to threefold increase in the number of [3H]PK11195 binding sites in cerebral cortex and kidney. A reduction in the number of [3H]PK11195 binding sites was observed in testis preparations, while the number of binding sites in the heart remained unaltered. These differences in the response of PTBRs to portacaval anastomosis, in different organs suggest that the physiological function of these receptors and the factors regulating them are modulated by distinct mechanisms. The finding of increased densities of [3H]PK11195 binding sites in brain and kidney following portacaval anastomosis parallels the cellular hypertrophy in these tissues and, together with previous observations of similar increases of these binding sites in brain and kidney in congenital hyperammonemia, suggest a pathophysiologic role for ammonia in these changes. In contrast, the significant loss of [3H]PK11195 binding sites in testicular preparations following portacaval anastomosis together with the known effects of steroid hormones on these sites suggests a role for PTBRs in the pathogenesis of testicular atrophy in chronic liver disease.
52 schema:genre research_article
53 schema:inLanguage en
54 schema:isAccessibleForFree false
55 schema:isPartOf Nd63f06fc54ac4a088f4e6fafb4348e33
56 Ne435c84b1e974e0e820f7cb01a20ba56
57 sg:journal.1018525
58 schema:name Tissue-specific alterations of binding sites for peripheral-type benzodiazepine receptor ligand [3H]PK11195 in rats following portacaval anastomosis
59 schema:pagination 1055-1063
60 schema:productId N02ad6bc7eae14a489bfaccd67e913a7c
61 N13554674770b4afca2b7f681ffc91c82
62 N4600040ee6234445b1f2d7cb6cef111a
63 N73b1f02ed0674b3495b7e53d9d1cdd03
64 Ndb12bfc6c2224911bcf0450a29bc6be6
65 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046479097
66 https://doi.org/10.1007/bf02087558
67 schema:sdDatePublished 2019-04-11T11:54
68 schema:sdLicense https://scigraph.springernature.com/explorer/license/
69 schema:sdPublisher N9e2bb14c471c4c8e879f3396b662777c
70 schema:url http://link.springer.com/10.1007/BF02087558
71 sgo:license sg:explorer/license/
72 sgo:sdDataset articles
73 rdf:type schema:ScholarlyArticle
74 N02ad6bc7eae14a489bfaccd67e913a7c schema:name dimensions_id
75 schema:value pub.1046479097
76 rdf:type schema:PropertyValue
77 N09c4ee63541b478bb9b7795f5dd104bf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
78 schema:name Cerebral Cortex
79 rdf:type schema:DefinedTerm
80 N12ffc27689b24449b44813b412890600 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
81 schema:name Testis
82 rdf:type schema:DefinedTerm
83 N13554674770b4afca2b7f681ffc91c82 schema:name nlm_unique_id
84 schema:value 7902782
85 rdf:type schema:PropertyValue
86 N39b2a32f40c64b65bd079315d9539774 rdf:first sg:person.0765176464.29
87 rdf:rest rdf:nil
88 N4600040ee6234445b1f2d7cb6cef111a schema:name readcube_id
89 schema:value dd6868e5e9950fda300495ca1f7437a928f6bd827a0c08f3935a64053a44517b
90 rdf:type schema:PropertyValue
91 N472ef82cc09e40a9b0b9c1aafaeee326 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Kidney
93 rdf:type schema:DefinedTerm
94 N4a03144655b84093b8ccbc3c70dac431 rdf:first sg:person.0721644076.95
95 rdf:rest N8bd4cd4740bc4bf7897a2c0b7682f639
96 N4bee59b8942947ba804ab1171d1355f0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Rats
98 rdf:type schema:DefinedTerm
99 N4d2be91b605e4e33a8d248463932764c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Myocardium
101 rdf:type schema:DefinedTerm
102 N59359ccc3c0d4e479669dffc1329bfb2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Male
104 rdf:type schema:DefinedTerm
105 N5ddee183396a487cabe0b14537248a9e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Animals
107 rdf:type schema:DefinedTerm
108 N5f42fcc7497e4c2dab343299c0882b1e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Portacaval Shunt, Surgical
110 rdf:type schema:DefinedTerm
111 N73b1f02ed0674b3495b7e53d9d1cdd03 schema:name pubmed_id
112 schema:value 8174418
113 rdf:type schema:PropertyValue
114 N8bd4cd4740bc4bf7897a2c0b7682f639 rdf:first sg:person.0767757276.25
115 rdf:rest Nc4efd86e992f4a9890050e0cd7849a85
116 N9e2bb14c471c4c8e879f3396b662777c schema:name Springer Nature - SN SciGraph project
117 rdf:type schema:Organization
118 Na19d20dc65d64bcfae92640814e0765e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Binding Sites
120 rdf:type schema:DefinedTerm
121 Na6a92f07640c4709897594aa9f3fc1cb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Receptors, GABA-A
123 rdf:type schema:DefinedTerm
124 Nb3242ab5c65c41299c0d0316f5769062 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Rats, Sprague-Dawley
126 rdf:type schema:DefinedTerm
127 Nc4efd86e992f4a9890050e0cd7849a85 rdf:first sg:person.01165473546.45
128 rdf:rest N39b2a32f40c64b65bd079315d9539774
129 Nd63f06fc54ac4a088f4e6fafb4348e33 schema:volumeNumber 39
130 rdf:type schema:PublicationVolume
131 Ndb12bfc6c2224911bcf0450a29bc6be6 schema:name doi
132 schema:value 10.1007/bf02087558
133 rdf:type schema:PropertyValue
134 Ne435c84b1e974e0e820f7cb01a20ba56 schema:issueNumber 5
135 rdf:type schema:PublicationIssue
136 Ne450aaadb4e448a592a3191be3ee6c8e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Isoquinolines
138 rdf:type schema:DefinedTerm
139 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
140 schema:name Medical and Health Sciences
141 rdf:type schema:DefinedTerm
142 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
143 schema:name Clinical Sciences
144 rdf:type schema:DefinedTerm
145 sg:journal.1018525 schema:issn 0163-2116
146 1573-2568
147 schema:name Digestive Diseases and Sciences
148 rdf:type schema:Periodical
149 sg:person.01165473546.45 schema:affiliation https://www.grid.ac/institutes/grid.14848.31
150 schema:familyName Therrien
151 schema:givenName Guy
152 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01165473546.45
153 rdf:type schema:Person
154 sg:person.0721644076.95 schema:affiliation https://www.grid.ac/institutes/grid.14848.31
155 schema:familyName Raghavendra Rao
156 schema:givenName V. L.
157 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721644076.95
158 rdf:type schema:Person
159 sg:person.0765176464.29 schema:affiliation https://www.grid.ac/institutes/grid.14848.31
160 schema:familyName Butterworth
161 schema:givenName Roger F.
162 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0765176464.29
163 rdf:type schema:Person
164 sg:person.0767757276.25 schema:affiliation https://www.grid.ac/institutes/grid.14848.31
165 schema:familyName Audet
166 schema:givenName Robert
167 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0767757276.25
168 rdf:type schema:Person
169 sg:pub.10.1007/bf00688851 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002522454
170 https://doi.org/10.1007/bf00688851
171 rdf:type schema:CreativeWork
172 sg:pub.10.1007/bf00999904 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009902663
173 https://doi.org/10.1007/bf00999904
174 rdf:type schema:CreativeWork
175 sg:pub.10.1203/00006450-199312000-00016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046106234
176 https://doi.org/10.1203/00006450-199312000-00016
177 rdf:type schema:CreativeWork
178 https://app.dimensions.ai/details/publication/pub.1076540342 schema:CreativeWork
179 https://app.dimensions.ai/details/publication/pub.1076664765 schema:CreativeWork
180 https://app.dimensions.ai/details/publication/pub.1076750128 schema:CreativeWork
181 https://app.dimensions.ai/details/publication/pub.1078391987 schema:CreativeWork
182 https://app.dimensions.ai/details/publication/pub.1078392916 schema:CreativeWork
183 https://app.dimensions.ai/details/publication/pub.1079421008 schema:CreativeWork
184 https://app.dimensions.ai/details/publication/pub.1079580406 schema:CreativeWork
185 https://app.dimensions.ai/details/publication/pub.1081547094 schema:CreativeWork
186 https://app.dimensions.ai/details/publication/pub.1081867515 schema:CreativeWork
187 https://app.dimensions.ai/details/publication/pub.1081993179 schema:CreativeWork
188 https://doi.org/10.1002/ana.410260109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024693499
189 rdf:type schema:CreativeWork
190 https://doi.org/10.1002/hep.1840110524 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024265416
191 rdf:type schema:CreativeWork
192 https://doi.org/10.1016/0006-8993(92)91222-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1037675819
193 rdf:type schema:CreativeWork
194 https://doi.org/10.1016/0014-2999(81)90092-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001543941
195 rdf:type schema:CreativeWork
196 https://doi.org/10.1016/0014-2999(83)90658-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035624099
197 rdf:type schema:CreativeWork
198 https://doi.org/10.1016/0014-2999(85)90026-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037312403
199 rdf:type schema:CreativeWork
200 https://doi.org/10.1016/0014-2999(86)90218-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004925465
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1016/0024-3205(81)90744-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1011271217
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1016/0091-3057(86)90504-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021343050
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1016/0165-6147(86)90438-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032285632
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1016/0196-9781(91)90177-q schema:sameAs https://app.dimensions.ai/details/publication/pub.1011355384
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1016/0304-3940(91)90408-l schema:sameAs https://app.dimensions.ai/details/publication/pub.1012476578
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1073/pnas.81.3.753 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045290299
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1073/pnas.84.8.2256 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034744495
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1097/00005072-197407000-00008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032165880
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1111/j.1365-2362.1976.tb00540.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1004064798
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1111/j.1471-4159.1990.tb05790.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1049124628
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1111/j.1471-4159.1992.tb10030.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1003801277
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1146/annurev.pa.22.040182.001333 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025149321
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1210/endo-116-2-567 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064258588
227 rdf:type schema:CreativeWork
228 https://www.grid.ac/institutes/grid.14848.31 schema:alternateName University of Montreal
229 schema:name From the Neuroscience Research Unit, Hôpital Saint-Luc, (University of Montreal), H2X 3J4, Montreal, Quebec, Canada
230 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...