Mechanisms of bombesin on growth of gastrinoma (PT)in vivo View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1996-11

AUTHORS

Kyo U. Chu, Jin Ishizuka, James F. Battey, Tatsuo Uchida, R. Daniel Beauchamp, Courtney M. Townsend, James C. Thompson

ABSTRACT

The growth of the human gastrinoma model (PT) in athymic nude mice is stimulated by bombesin (BBS), an amphibian peptide homologous to both human gastrin-releasing peptide (GRP) and neuromedin B (NMB). The mechanism is not known, and a potent and specific GRP-R antagonist BIM26226, which has low affinity for NMB-R, was used in vivo in athymic nude mice bearing gastrinoma subcutaneously. Both the BBS and BIM26226 stimulated the growth of PT, and the growth stimulation was even greater when given together. RT-PCR study of gastrinoma revealed the presence of both GRP-R and NMB-R mRNA, but much more abundant NMB-R mRNA. We conclude that BBS-stimulated growth of gastrinoma involves both GRP-R and NMB-R, and our findings suggest that GRP-R mediates negative and NMB-R produces positive growth effects on gastrinoma. More... »

PAGES

2180-2186

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf02071398

DOI

http://dx.doi.org/10.1007/bf02071398

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1004170679

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/8943970


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303 schema:name Division of Intramural Research, National Institute on Deafness and Other Communication Disorders, NIH, 20892, Bethesda, Maryland
304 From the Departments of Surgery and Biostatistics, The University of Texas Medical Branch, 77555, Galveston, Texas
305 rdf:type schema:Organization
 




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