Autoimmune cholangitis: A variant of primary biliary cirrhosis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1995-06

AUTHORS

Zachary D. Goodman, Peter R. McNally, Dirk R. Davis, Kamal G. Ishak

ABSTRACT

The term "autoimmune cholangitis" is used for a disease with clinical and pathologic features of primary biliary cirrhosis (PBC) but with negative anti-mitochondrial antibody (AMA) and positive anti-nuclear antibody (ANA) tests. In order to characterize autoimmune cholangitis and to determine whether this truly differs from PBC, we reviewed 200 cases morphologically consistent with PBC in which data on AMA and ANA status were available to us. Of these, 64 (32%) had a negative AMA, 114 (57%) had a positive ANA, and 40 (20%) had negative AMA and positive ANA (autoimmune cholangitis). The AMA-negative group was slightly younger on average (50 vs 55 years) than AMA positives (P < 0.05). There were no significant differences in gender (15.5% male overall), hepatic histopathology, or other laboratory tests between the groups of patients with any of the 4 possible combinations of AMA and ANA. Since the only consistently distinguishing feature among these patients is the autoantibody (AMA and ANA) profile, and they otherwise have virtually identical clinical and histopathologic features, autoimmune cholangitis can be considered to be the same as AMA-negative PBC. More... »

PAGES

1232-1242

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf02065530

DOI

http://dx.doi.org/10.1007/bf02065530

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1021092652

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/7781439


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