Improved net sodium transport of the isolated rat kidney View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1971-12

AUTHORS

H. Franke, H. Huland, Ch. Weiss, K. Unsicker

ABSTRACT

Employing a non-ionic detergent as a colloidosmotically active substance 10 fully isolated rat kidneys were perfused for 60 min. A constant glomerular filtration rate (GFR) of 1.0 ml × g−1 × min−1 and a mean Na+-net transport of about 92 μmol × g−1 × min−1 was obtained. The mean O2-consumption of 0.17 ml × g−1 × min−1 was rather high. However, addition of the decoupling agent 2,4-dinitrophenol led to an increase of the O2-consumption by 98%, thus speaking against spontaneous uncoupling. Glomerula, proximal and distal convoluted tubules of kidneys perfused with plasmaexpander-solutions were studied electronmicroscopically. The most striking morphological deviations were found in the proximal tubules of the Haemaccel®-perfused kidneys. In the Pluronic®-kidneys significantly less morphological alterations were found. These morphological changes were of a type which was previously described by other investigators after periods of hypoxia. More... »

PAGES

268-282

References to SciGraph publications

  • 1955-07. Histologische, cytochemische und elektronenmikroskopische Untersuchungen am Nephron in CELL AND TISSUE RESEARCH
  • 1963-07. Studien über die Folgen einer vorübergehenden experimentellen Nierenischämie in VIRCHOWS ARCHIV A PATHOLOGICAL ANATOMY AND HISTOPATHOLOGY
  • 1967-09. Functional capacity of the isolated perfused dog kidney in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • 1969-12. The oxygen supply of the rat kidney: Measurements of intrarenalpO2 in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • 1965-09. Herstellung und Funktion eines isolierten Nierenpräparates vom Hund in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/bf02045828

    DOI

    http://dx.doi.org/10.1007/bf02045828

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1021942072

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/5144490


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