Excimer laser angioplasty: Quantitative comparison in vitro of three ultraviolet wavelengths on tissue ablation and haemolysis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1986-04

AUTHORS

T. J. Bowker, F. W. Cross, P. T. Rumsby, M. C. Gower, A. F. Rickards, S. G. Bown

ABSTRACT

The effects of three ultraviolet excimer laser wavelengths on normal and atheromatous human cadaver aortic wall are presented. Ultraviolet radiation successfully ablates vessel wall; the dose response is greatest at 249 nm followed by 193 nm and 351 nm, where the effect is negligible for the equivalent energy dose. Wavelengths 249 and 193 nm have a selective effect on fibrous atheroma; ablation proceeds at a higher rate in this tissue. Non-linear effects observed at 249 nm may be due to thermal as well as photoablative mechanisms. In addition, blood samples were exposed to all three wavelengths and potassium concentrations were measured; the dose of energy required to produce tissue ablation may also produce significant haemolysis and hyperkalaemia at 249 and 193 nm but not with 351 nm. This finding may be important for coronary angioplasty but less so for peripheral work. The wavelength that produces the strongest dose response is 249 nm; this is the wavelength for which a fibre-optic delivery system should be developed. More... »

PAGES

91-100

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf02038956

DOI

http://dx.doi.org/10.1007/bf02038956

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1043004197


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