153Sm metallic-hydroxide macroaggregates: An improved preparation for radiation synovectomy View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1997-08

AUTHORS

G. Ferro-Flores, L. García-Salinas, M. Pedraza-López, M. A. González-Zavala, J. I. Tendilla, M. A. López-Gómez

ABSTRACT

A new type of preparation employing153Sm metallic-hydroxide macroaggregates (153Sm-MHM) for radiation synovectomy was developed. The radiopharmaceutical was prepared by reacting the aqueous solution of153SmCl3 with sodium borohydride solution in 0.5N NaOH. Microscopic analysis showed that153Sm-MHM mean particle size was 4 μm (range 1–15 μm) avoiding the formation of fine particles (<1 μm) which were153Sm-hydroxide macroaggregates preparations (153Sm-HM). Also, suspension properties as sedimentation rate, were better for153Sm-MHM than for153Sm-hydroxyapatite and153Sm-HM. Biological studies in normal rabbits demonstrated high retention into de Knee joint space even at 48 h after administration of153Sm-MHM (>99%). More... »

PAGES

93-97

References to SciGraph publications

  • 1990-08. Dysprosium (165Dy) hydroxide macroaggregates for radiation synovectomy — animal studies in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/bf02034253

    DOI

    http://dx.doi.org/10.1007/bf02034253

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1027059886


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