Effect of Ambroxol of neutrophil chemotaxisin vitro View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1988-07

AUTHORS

R. A. Stockley, J. Shaw, D. Burnett

ABSTRACT

Ambroxol hydrochloride has been shown to protect the lung from damage by polymorphonuclear leucocyte (PMN). In view of this observation we have studied the effect of Ambroxol on PMN chemotaxis using a variety of chemoattractants. The PMN response was inhibited 50–80% by preincubating the cells with concentrations of 10−4M Ambroxol. There was no evidence of PMN killing by the drug at concentration of 10−3M. The results suggest that Ambroxol my have a role in the management of patients whose chronic lung damage is due to excess PMN recruitment. More... »

PAGES

292-296

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf02028285

DOI

http://dx.doi.org/10.1007/bf02028285

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1033605893

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/3177092


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